4.7 Article

Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

MicroRNA-34a-5p serves as a tumor suppressor by regulating the cell motility of bladder cancer cells through matrix metalloproteinase-2 silencing

Kuang-Yu Chou et al.

Summary: hsa-miR-34a plays a role in inhibiting cell migration and invasion in bladder cancer by silencing matrix metalloproteinase-2 (MMP-2) expression, thus interrupting MMP-2-mediated cell motility.

ONCOLOGY REPORTS (2021)

Article Biochemistry & Molecular Biology

miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells

Rieko Aida et al.

Summary: Apigenin induces apoptosis in A549 cells by down-regulating SNAI1 through up-regulating miR-34a-5p.

MOLECULAR BIOLOGY REPORTS (2021)

Review Oncology

AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew

Almira Auyez et al.

Summary: AXL is a crucial receptor tyrosine kinase involved in various functions in cancer progression, including promoting cell survival and metastasis, suppressing immune responses, and enhancing drug resistance. By studying the molecular mechanisms of AXL, researchers can develop more effective anti-cancer therapeutics.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies

Stefania Pizzimenti et al.

Summary: Melanoma is a highly aggressive cancer with activating mutations in BRAF being the most common genetic alterations. Targeted inhibitors have improved survival rates in advanced melanoma patients, but resistance still develops in around 50% of patients within the first year of therapy, presenting a significant challenge in managing BRAF-mutated advanced melanoma. Understading the mechanisms of resistance, including genetic, epigenetic, and oxidative stress-related factors, is crucial in developing effective therapies.

ANTIOXIDANTS (2021)

Article Cell Biology

miR-34a inhibits melanoma growth by targeting ZEB1

Yazhen Xu et al.

Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.

AGING-US (2021)

Article Medicine, Research & Experimental

The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma

Mohammad Malekan et al.

Summary: The adaptation to O2 loss is regulated by hypoxia-inducible factors such as HIF-1 alpha, which plays a crucial role in melanoma progression through various signaling pathways. Therefore, HIF-1 alpha serves as a diagnostic/prognostic biomarker and a potential target for therapy in melanoma.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme

Giovanni Gotte et al.

Summary: ONC is a monomeric amphibian pancreatic-type RNase with remarkable anticancer activity that can form a dimer (ONC-D) which retains catalytic activity and displays antitumor effects in melanoma cell lines by inhibiting the expression of Bcl2 and STAT-3. The study reveals the unexpected variability in quaternary assembly and open interface arrangement upon domain swapping, providing insights into the differences in biological activities of ONC and ONC-D.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Cell Biology

Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression

Gang Ma et al.

Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.

CELL DEATH & DISEASE (2021)

Review Biochemistry & Molecular Biology

Expression and function of FRA1 protein in tumors

Xiaoyan Jiang et al.

MOLECULAR BIOLOGY REPORTS (2020)

Review Biochemistry & Molecular Biology

Regulatory Mechanism of MicroRNA Expression in Cancer

Zainab Ali Syeda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, Research & Experimental

Function and mechanisms of microRNA-20a in colorectal cancer

Zheng Xiao et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Review Biochemistry & Molecular Biology

The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications' door

Francesco Talotta et al.

ONCOGENE (2020)

Article Pharmacology & Pharmacy

Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells

Alice Raineri et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Biotechnology & Applied Microbiology

MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis

Ping Nan et al.

ONCOTARGETS AND THERAPY (2019)

Article Biochemistry & Molecular Biology

Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability

Alice Raineri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

The biochemical basis of microRNA targeting efficacy

Sean E. McGeary et al.

SCIENCE (2019)

Review Oncology

1 A Systematic Review of miR-29 in Cancer

Jason J. Kwon et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

Article Oncology

Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma

Milad Asadi et al.

JOURNAL OF GASTROINTESTINAL CANCER (2019)

Article Cell Biology

MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation

Nai-yuan Shao et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma

Qiang Zuo et al.

ONCOGENE (2018)

Article Multidisciplinary Sciences

Angiogenic role of miR-20a in breast cancer

Gines Luengo-Gil et al.

PLOS ONE (2018)

Article Oncology

UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling

Anushka Dikshit et al.

CANCER RESEARCH (2018)

Review Oncology

Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers

Z. Ping Lin et al.

FRONTIERS IN ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

HGF/c-MET Signaling in Melanocytes and Melanoma

Malgorzata Czyz

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Pharmacology & Pharmacy

Targeting metabolic reprogramming as a potential therapeutic strategy in melanoma

Lorey K. Smith et al.

PHARMACOLOGICAL RESEARCH (2016)

Article Biotechnology & Applied Microbiology

Restoration of miR-20a expression suppresses cell proliferation, migration, and invasion in HepG2 cells

Guang Shun Chen et al.

ONCOTARGETS AND THERAPY (2016)

Review Medical Laboratory Technology

LncRNAs and neoplasia

Mustafa Isin et al.

CLINICA CHIMICA ACTA (2015)

Article Genetics & Heredity

Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells

Anna Laurenzana et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Article Biochemistry & Molecular Biology

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

Rupert Courtnay et al.

MOLECULAR BIOLOGY REPORTS (2015)

Article Medicine, Research & Experimental

Mir-34: A New Weapon Against Cancer?

Gabriella Misso et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2014)

Article Biochemistry & Molecular Biology

MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1

S. Yang et al.

ONCOGENE (2013)

Review Oncology

Emerging molecular targets in melanoma invasion and metastasis

Jose L. Orgaz et al.

PIGMENT CELL & MELANOMA RESEARCH (2013)

Article Medicine, Research & Experimental

SOX2 contributes to melanoma cell invasion

Sasha D. Girouard et al.

LABORATORY INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support

Thanasis Vergoulis et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

doRiNA: a database of RNA interactions in post-transcriptional regulation

Gerd Anders et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Cell Biology

Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

Natalia G. Starostina et al.

TRENDS IN CELL BIOLOGY (2012)

Article Biochemical Research Methods

VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R

Hanbo Chen et al.

BMC BIOINFORMATICS (2011)

Article Biochemistry & Molecular Biology

miRTarBase: a database curates experimentally validated microRNA-target interactions

Sheng-Da Hsu et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Biochemistry & Molecular Biology

DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association

Manolis Maragkakis et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Biochemistry & Molecular Biology

Onconase mediated NFKβ downregulation in malignant pleural mesothelioma

C. M. Goparaju et al.

ONCOGENE (2011)

Article Oncology

Constitutive HIF-1 activity in malignant melanoma

Silke Kuphal et al.

EUROPEAN JOURNAL OF CANCER (2010)

Article Biochemistry & Molecular Biology

miRecords: an integrated resource for microRNA-target interactions

Feifei Xiao et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Ophthalmology

MicroRNA-34a Inhibits Uveal Melanoma Cell Proliferation and Migration through Downregulation of c-Met

Dongsheng Yan et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Biochemistry & Molecular Biology

miRBase: tools for microRNA genomics

Sam Griffiths-Jones et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemistry & Molecular Biology

The microRNA.org resource: targets and expression

Doron Betel et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Genetics & Heredity

The role of site accessibility in microRNA target recognition

Michael Kertesz et al.

NATURE GENETICS (2007)

Article Biochemistry & Molecular Biology

Cytotoxic ribonucleases: The dichotomy of coulombic forces

R. Jeremy Johnson et al.

BIOCHEMISTRY (2007)

Article Biochemical Research Methods

Inference of miRNA targets using evolutionary conservation and pathway analysis

Dimos Gaidatzis et al.

BMC BIOINFORMATICS (2007)

Review Biochemistry & Molecular Biology

RB and cell cycle progression

C. Giacinti et al.

ONCOGENE (2006)

Article Biotechnology & Applied Microbiology

Ranpirnase - an antitumour ribonuclease: its potential role in malignant mesothelioma

N Pavlakis et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2006)

Article Multidisciplinary Sciences

The functions of animal microRNAs

V Ambros

NATURE (2004)

Article Biochemistry & Molecular Biology

Onconase: An unusually stable protein

E Notomista et al.

BIOCHEMISTRY (2000)