4.7 Review

Blood-Brain Barrier in Brain Tumors: Biology and Clinical Relevance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy

So Hee Park et al.

Summary: This study evaluated the safety and feasibility of repeated disruption of the blood-brain barrier with MR-guided focused ultrasound in patients with glioblastoma during standard chemotherapy, showing accurate and safe performance without clinical adverse effects.

JOURNAL OF NEUROSURGERY (2021)

Article Oncology

Phase I study of liposomal irinotecan in patients with metastatic breast cancer: findings from the expansion phase

Jasgit C. Sachdev et al.

Summary: The study evaluated the efficacy and safety of liposomal irinotecan in heavily pretreated patients with metastatic breast cancer. The results showed antitumor activity of monotherapy in all cohorts and a consistent safety profile with previous studies.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Review Endocrinology & Metabolism

Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview

Ekram Ahmed Chowdhury et al.

Summary: This review discusses the significance of the blood-brain barrier in drug delivery and the evolution of different pharmacokinetic techniques in measuring brain uptake and permeability of small molecules. It emphasizes the importance of utilizing the right method to properly assess CNS exposure and acknowledges the progress made while recognizing the need to reduce failures in central nervous system drug development programs.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Review Pharmacology & Pharmacy

Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor

Sheng-Kai Wu et al.

Summary: The presence of blood-brain barriers is a major obstacle in effectively delivering therapeutics to the central nervous system, especially in treating malignant brain tumors. Conventional methods have not been successful, but techniques like convention-enhanced delivery and focused ultrasound show promise in overcoming this challenge.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems

Kanawat Wiwatchaitawee et al.

Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor, with current treatments including surgery, radiation, and chemotherapy, while nanoparticle-mediated delivery systems show promise. Drug delivery via nanoparticles can reduce toxicity, increase specificity, and improve survival and quality of life for GBM patients.

AAPS PHARMSCITECH (2021)

Review Medicine, Research & Experimental

Basic physiology of the blood-brain barrier in health and disease: a brief overview

Mehmet Kaya et al.

Summary: The blood-brain barrier (BBB) is a dynamic interface mainly composed of brain microvascular endothelial cells, which restricts harmful substances and cells from entering the brain while also preventing therapeutic drugs from reaching the brain effectively. Disruption of BBB integrity may contribute to the pathogenesis of neurodegenerative diseases, and certain diseases like Alzheimer's, hypertension, and epilepsy are associated with varying degrees of BBB disruption. Innovative brain drug delivery strategies aim to overcome the obstacle presented by the BBB for effective pharmacological treatment of neurodegenerative diseases.

TISSUE BARRIERS (2021)

Article Chemistry, Multidisciplinary

Molecularly Imprinted Nanoparticles for Biomedical Applications

Huiqi Zhang

ADVANCED MATERIALS (2020)

Review Oncology

Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

Peter T. Harrison et al.

SEMINARS IN CANCER BIOLOGY (2020)

Review Pharmacology & Pharmacy

The blood-brain barrier: Physiology and strategies for drug delivery

Rucha Pandit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Medicine, General & Internal

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

R. K. Murthy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Clinical Neurology

Management of brain metastases according to molecular subtypes

Riccardo Soffietti et al.

NATURE REVIEWS NEUROLOGY (2020)

Review Pharmacology & Pharmacy

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review

Keisuke Tachibana et al.

PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors

Jessica I. Griffith et al.

PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

Blood-Brain Barrier Modulation to Improve Glioma Drug Delivery

Huilong Luo et al.

PHARMACEUTICS (2020)

Review Oncology

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases

Costas D. Arvanitis et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

CAR T cells for brain tumors: Lessons learned and road ahead

David Akhavan et al.

IMMUNOLOGICAL REVIEWS (2019)

Review Biochemistry & Molecular Biology

Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance

Candice Chapouly et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells

Iris Chiara Salaroglio et al.

MOLECULAR PHARMACEUTICS (2019)

Review Physiology

BLOOD-BRAIN BARRIER: FROM PHYSIOLOGY TO DISEASE AND BACK

Melanie D. Sweeney et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Clinical Neurology

Basement membrane and blood-brain barrier

Lingling Xu et al.

STROKE AND VASCULAR NEUROLOGY (2019)

Editorial Material Oncology

Moving treatments earlier to move further forwards

Michael A. Davies et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Clinical Neurology

Management of leptomeningeal metastasis in breast cancer

Hazem I. Assi et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2018)

Article Chemistry, Multidisciplinary

Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

Satoshi Zeniya et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Cell Biology

Mechanisms of clathrin-mediated endocytosis

Marko Kaksonen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Oncology

Breast cancer brain metastasis: molecular mechanisms and directions for treatment

Rute M. S. M. Pedrosa et al.

NEURO-ONCOLOGY (2018)

Article Cell & Tissue Engineering

Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

Rachael Mooney et al.

STEM CELLS INTERNATIONAL (2018)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Multidisciplinary Sciences

The biology and management of non-small cell lung cancer

Roy S. Herbst et al.

NATURE (2018)

Editorial Material Neurosciences

Brain barriers in health and disease

Richard Daneman et al.

NEUROBIOLOGY OF DISEASE (2017)

Article Medicine, General & Internal

Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer

Solange Peters et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Medicine, Research & Experimental

Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities

Colleen T. Curley et al.

THERANOSTICS (2017)

Article Multidisciplinary Sciences

Architecture of the paracellular channels formed by claudins of the blood-brain barrier tight junctions

Flaviyan Jerome Irudayanathan et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Review Clinical Neurology

Microglia-blood vessel interactions: a double-edged sword in brain pathologies

Nevenka Dudvarski Stankovic et al.

ACTA NEUROPATHOLOGICA (2016)

Editorial Material Endocrinology & Metabolism

What is a pericyte?

David Attwell et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

Article Oncology

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

Timothy N. Phoenix et al.

CANCER CELL (2016)

Review Oncology

Development of polymeric micelles for targeting intractable cancers

Nobuhiro Nishiyama et al.

CANCER SCIENCE (2016)

Review Pharmacology & Pharmacy

CSF, blood-brain barrier, and brain drug delivery

William M. Pardridge

EXPERT OPINION ON DRUG DELIVERY (2016)

Article Biochemistry & Molecular Biology

Effects of GSM modulated radio-frequency electromagnetic radiation on permeability of blood-brain barrier in male & female rats

Bahriye Sirav et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2016)

Review Medicine, Research & Experimental

Tight junction modulation of the blood brain barrier: CNS delivery of small molecules

Chris Greene et al.

TISSUE BARRIERS (2016)

Review Physiology

The neurovascular unit - concept review

V. Muoio et al.

ACTA PHYSIOLOGICA (2014)

Article Multidisciplinary Sciences

Capillary pericytes regulate cerebral blood flow in health and disease

Catherine N. Hall et al.

NATURE (2014)

Article Multidisciplinary Sciences

Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice

Nikolett Sandor et al.

PLOS ONE (2014)

Review Oncology

Stem cell-based therapies for cancer treatment: separating hope from hype

Daniel W. Stuckey et al.

NATURE REVIEWS CANCER (2014)

Article Nanoscience & Nanotechnology

Photoactivation of gold nanoparticles for glioma treatment

Laure Bobyk et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)

Review Biochemistry & Molecular Biology

Advances in stem cell therapy against gliomas

M. Sarah S. Bovenberg et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Article Pharmacology & Pharmacy

Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain

Rajneet K. Oberoi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

Article Oncology

Epidemiology of Brain Metastases

Lakshmi Nayak et al.

CURRENT ONCOLOGY REPORTS (2012)

Review Cell Biology

Macropinocytosis: an endocytic pathway for internalising large gulps

Jet Phey Lim et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

Article Chemistry, Multidisciplinary

Size and shape effects in the biodistribution of intravascularly injected particles

P. Decuzzi et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Article Clinical Neurology

Poor drug distribution as a possible explanation for the results of the PRECISE trial Clinical article

John H. Sampson et al.

JOURNAL OF NEUROSURGERY (2010)

Review Neurosciences

Structure and function of the blood-brain barrier

N. Joan Abbott et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Clinical Neurology

Characteristics of compounds that cross the blood-brain barrier

William A. Banks

BMC NEUROLOGY (2009)

Review Biotechnology & Applied Microbiology

Modelling of the blood-brain barrier in drug discovery and development

Romeo Cecchelli et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Review Radiology, Nuclear Medicine & Medical Imaging

Hypointensities in the Brain on T2*-Weighted Gradient-Echo Magnetic Resonance Imaging

Yoshito Tsushima et al.

CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY (2006)

Article Neurosciences

Astrocyte-mediated control of cerebral blood flow

T Takano et al.

NATURE NEUROSCIENCE (2006)

Article Pharmacology & Pharmacy

Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier

NS Ningaraj et al.

DRUG NEWS & PERSPECTIVES (2003)

Article Oncology

Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: Clinical results

DX Qin et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2001)