期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/ijms221910348
关键词
estrogen receptor beta; follicle stimulating hormone; luteinizing hormone; steroidogenesis; follicle development; oocyte maturation; ovulation
资金
- KUMC SOM
- COBRE [P30 GM122731]
- K-INBRE [P20 GM103418]
Gonadotropins play vital roles in ovarian development and oocyte maturation, signaling through protein kinases and regulated by estrogen receptors. Er beta is crucial in regulating follicle development and ovulation.
Gonadotropins are essential for regulating ovarian development, steroidogenesis, and gametogenesis. While follicle stimulating hormone (FSH) promotes the development of ovarian follicles, luteinizing hormone (LH) regulates preovulatory maturation of oocytes, ovulation, and formation of corpus luteum. Cognate receptors of FSH and LH are G-protein coupled receptors that predominantly signal through cAMP-dependent and cAMP-independent mechanisms that activate protein kinases. Subsequent vital steps in response to gonadotropins are mediated through activation or inhibition of transcription factors required for follicular gene expression. Estrogen receptors, classical ligand-activated transcriptional regulators, play crucial roles in regulating gonadotropin secretion from the hypothalamic-pituitary axis as well as gonadotropin function in the target organs. In this review, we discuss the role of estrogen receptor beta (ER beta) regulating gonadotropin response during folliculogenesis. Ovarian follicles in Er beta knockout (Er beta(KO)) mutant female mice and rats cannot develop beyond the antral state, lack oocyte maturation, and fail to ovulate. Theca cells (TCs) in ovarian follicles express LH receptor, whereas granulosa cells (GCs) express both FSH receptor (FSHR) and LH receptor (LHCGR). As oocytes do not express the gonadotropin receptors, the somatic cells play a crucial role during gonadotropin induced oocyte maturation. Somatic cells also express high levels of estrogen receptors; while TCs express ER alpha and are involved in steroidogenesis, GCs express ER beta and are involved in both steroidogenesis and folliculogenesis. GCs are the primary site of ER beta-regulated gene expression. We observed that a subset of gonadotropin-induced genes in GCs, which are essential for ovarian follicle development, oocyte maturation and ovulation, are dependent on ER beta. Thus, ER beta plays a vital role in regulating the gonadotropin responses in ovary.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据