Staphylococcus aureus-A Known Opponent against Host Defense Mechanisms and Vaccine Development-Do We Still Have a Chance to Win?

The main purpose of this review is to present justification for the urgent need to implement specific prophylaxis of invasive Staphylococcus aureus infections. We emphasize the difficulties in achieving this goal due to numerous S. aureus virulence factors important for the process of infection and the remarkable ability of these bacteria to avoid host defense mechanisms. We precede these considerations with a brief overview of the global necessitiy to intensify the use of vaccines against other pathogens as well, particularly in light of an impasse in antibiotic therapy. Finally, we point out global trends in research into modern technologies used in the field of molecular microbiology to develop new vaccines. We focus on the vaccines designed to fight the infections caused by S. aureus, which are often resistant to the majority of available therapeutic options.

Automated summary

The main purpose of this review is to justify the urgent need for implementing specific prophylaxis for invasive Staphylococcus aureus infections. The difficulties in achieving this goal are emphasized due to the virulence factors of S. aureus important for infection and their ability to avoid host defense mechanisms. The global necessity to intensify the use of vaccines against other pathogens and the trends in research on modern technologies for developing new vaccines in the field of molecular microbiology are also highlighted.