期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ijms222413293
关键词
aryl hydrocarbon receptor; species differences; mechanism; ligand-binding domain; dioxin response element
资金
- National Natural Science Foundation of China (National Natural Science Foundation of China) [82074115, 81873084, 81773827, 81673684, 81703626]
- Double First-Class University project [CPU2018GY06]
This review systematically discusses the species differences in AhR activation effects and their modes of action, focusing on molecular configuration and activation of AhR, as well as comparison of cis-acting elements corresponding to AhR. The variations in responses seen in humans and other species following AhR activation can be attributed to both factors.
The aryl hydrocarbon receptor (AhR) is a transcription factor that regulates a wide range of biological and toxicological effects by binding to specific ligands. AhR ligands exist in various internal and external ecological systems, such as in a wide variety of hydrophobic environmental contaminants and naturally occurring chemicals. Most of these ligands have shown differential responses among different species. Understanding the differences and their mechanisms helps in designing better experimental animal models, improves our understanding of the environmental toxicants related to AhR, and helps to screen and develop new drugs. This review systematically discusses the species differences in AhR activation effects and their modes of action. We focus on the species differences following AhR activation from two aspects: (1) the molecular configuration and activation of AhR and (2) the contrast of cis-acting elements corresponding to AhR. The variations in the responses seen in humans and other species following the activation of the AhR signaling pathway can be attributed to both factors.
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