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Telomere Shortening and Its Association with Cell Dysfunction in Lung Diseases

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis

Yanhua Kang et al.

CELL REPORTS (2018)

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Article Immunology

Proximity of Cytomegalovirus-Specific CD8+ T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals

John Joseph Heath et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Endocrinology & Metabolism

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Claudio Franceschi et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

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Article Cell Biology

Azithromycin and Roxithromycin define a new family of senolytic drugs that target senescent human fibroblasts

Bela Ozsvari et al.

AGING-US (2018)

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Article Medicine, Research & Experimental

Short telomere syndromes cause a primary T cell immunodeficiency

Christa L. Wagner et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Respiratory System

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Marc A. Sala et al.

RESPIRATORY RESEARCH (2018)

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Article Medicine, Research & Experimental

mTOR pathway activation drives lung cell senescence and emphysema

Amal Houssaini et al.

JCI INSIGHT (2018)

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Article Obstetrics & Gynecology

Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length

Hooman Mirzakhani et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2017)

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Review Cell Biology

Telomere-driven diseases and telomere-targeting therapies

Paula Martinez et al.

JOURNAL OF CELL BIOLOGY (2017)

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Article Cell Biology

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

Seyung S. Chung et al.

MEDIATORS OF INFLAMMATION (2017)

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Article Multidisciplinary Sciences

The Maintenance of Telomere Length in CD28+T Cells During T Lymphocyte Stimulation

Ejun (Elijah) Huang et al.

SCIENTIFIC REPORTS (2017)

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Article Respiratory System

Serum IL-1 beta and IL-17 levels in patients with COPD: associations with clinical parameters

Yong Zou et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2017)

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Article Critical Care Medicine

The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study

Brett Ley et al.

LANCET RESPIRATORY MEDICINE (2017)

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Article Immunology

Clinical and Molecular Heterogeneity of RTEL1 Deficiency

Carsten Speckmann et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Physiology

IPF lung fibroblasts have a senescent phenotype

Diana Alvarez et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

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Article Cell Biology

Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease

Chunsun Jiang et al.

AGING CELL (2017)

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Article Cell Biology

Quantitative identification of senescent cells in aging and disease

Anat Biran et al.

AGING CELL (2017)

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Article Biochemistry & Molecular Biology

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease

Tanveer Ahmad et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

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Article Hematology

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

Christian Bar et al.

BLOOD (2016)

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Article Respiratory System

Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive

Chad A. Newton et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

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Article Medicine, General & Internal

Danazol Treatment for Telomere Diseases

Danielle M. Townsley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Biotechnology & Applied Microbiology

Shorter telomere length of T-cells in peripheral blood of patients with lung cancer

Yaqin Qian et al.

ONCOTARGETS AND THERAPY (2016)

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Article Medicine, Research & Experimental

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

Ram P. Naikawadi et al.

JCI INSIGHT (2016)

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Article Cell Biology

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu et al.

AGING CELL (2015)

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Article Respiratory System

Hallmarks of the ageing lung

Silke Meiners et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

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Article Immunology

Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults

Kevin Najarro et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

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Article Multidisciplinary Sciences

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

Zhuo Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Oncology

miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway

Xinsen Xu et al.

ONCOTARGET (2015)

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Article Oncology

Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

Matthew N. Bainbridge et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Article Critical Care Medicine

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

Phillip L. Molyneaux et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Hematology

Response to androgen therapy in patients with dyskeratosis congenita

Payal P. Khincha et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

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Article Oncology

Telomere Shortening Is Associated with Genetic Anticipation in Chinese Von Hippel-Lindau Disease Families

Xiang-hui Ning et al.

CANCER RESEARCH (2014)

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Article Geriatrics & Gerontology

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Claudio Franceschi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

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Article Medicine, General & Internal

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Talmadge E. King et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Multidisciplinary Sciences

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Diana Jurk et al.

NATURE COMMUNICATIONS (2014)

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Review Biochemistry & Molecular Biology

Telomere shortening in human diseases

Chiou Mee Kong et al.

FEBS JOURNAL (2013)

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Article Biochemistry & Molecular Biology

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

Karen A. Pooley et al.

HUMAN MOLECULAR GENETICS (2013)

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Letter Allergy

Are leukocytes in asthmatic patients aging faster? A study of telomere length and disease severity

Shigenori Kyoh et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Genetics & Heredity

Identification of seven loci affecting mean telomere length and their association with disease

Veryan Codd et al.

NATURE GENETICS (2013)

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Review Medical Laboratory Technology

Telomeres in lung disease

John M. Gansner et al.

TRANSLATIONAL RESEARCH (2013)

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Article Genetics & Heredity

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

Bari J. Ballew et al.

PLOS GENETICS (2013)

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Article Critical Care Medicine

Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

Valerie Amsellem et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

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Article Pathology

Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis

Daniel Reis Waisberg et al.

HUMAN PATHOLOGY (2010)

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Article Cell Biology

Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents

Christian Jung et al.

MEDIATORS OF INFLAMMATION (2010)

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Article Oncology

CD8+CD28-cells and CD4+CD25+regulatory T cells in the peripheral blood of advanced stage lung cancer patients

Bulent Karagoz et al.

MEDICAL ONCOLOGY (2010)

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Article Cell Biology

Telomere length regulates ISG15 expression in human cells

Zhenjun Lou et al.

AGING-US (2009)

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Article Biochemistry & Molecular Biology

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

Agnel Sfeir et al.

CELL (2009)

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Article Immunology

Blockade of LOX-1 Prevents Endotoxin-Induced Acute Lung Inflammation and Injury in Mice

Ping Zhang et al.

JOURNAL OF INNATE IMMUNITY (2009)

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Article Biochemistry & Molecular Biology

Functional Dissection of Human and Mouse POT1 Proteins

Wilhelm Palm et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

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Article Critical Care Medicine

Telomere shortening in familial and sporadic pulmonary fibrosis

Jennifer T. Cronkhite et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

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Article Immunology

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

Steven Russell Fauce et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

Jonathan K. Alder et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Biochemistry & Molecular Biology

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean-Philippe Coppe et al.

PLOS BIOLOGY (2008)

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Article Cell Biology

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II

Stefan Schoeftner et al.

NATURE CELL BIOLOGY (2008)

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Article Oncology

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence

Qin Yang et al.

CANCER RESEARCH (2007)

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Article Multidisciplinary Sciences

Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends

Claus M. Azzalin et al.

SCIENCE (2007)

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Article Multidisciplinary Sciences

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Kalliopi D. Tsakiri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Review Cell Biology

Shelterin: the protein complex that shapes and safeguards human telomeres

T de Lange

GENES & DEVELOPMENT (2005)

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Article Biochemistry & Molecular Biology

Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2

WH Li et al.

EMBO JOURNAL (2005)

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Review Biochemistry & Molecular Biology

Beginning to understand the end of the chromosome

TR Cech

CELL (2004)

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Article Biochemistry & Molecular Biology

Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening

S Oikawa et al.

BIOCHEMISTRY (2001)

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Article Virology

Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8+ T lymphocytes in healthy seropositive donors

GMA Gillespie et al.

JOURNAL OF VIROLOGY (2000)

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