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Joon-Il Jun et al.
NATURE CELL BIOLOGY (2010)
Alternative splicing and evolution: diversification, exon definition and function
Hadas Keren et al.
NATURE REVIEWS GENETICS (2010)
SENESCENCE Senescence in tumours: evidence from mice and humans
Manuel Collado et al.
NATURE REVIEWS CANCER (2010)
DNA damage response and cellular senescence in tissues of aging mice
Chunfang Wang et al.
AGING CELL (2009)
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
Sandhya Sanduja et al.
AGING-US (2009)
MicroRNAs: Target Recognition and Regulatory Functions
David P. Bartel
CELL (2009)
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Marina Chekulaeva et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
Marta Barradas et al.
GENES & DEVELOPMENT (2009)
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
Karl Agger et al.
GENES & DEVELOPMENT (2009)
Autophagy mediates the mitotic senescence transition
Andrew R. J. Young et al.
GENES & DEVELOPMENT (2009)
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
Olga Moiseeva et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions
Anthony J. Cesare et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
Arturo V. Orjalo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Lysosomes and oxidative stress in aging and apoptosis
Tino Kurz et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2008)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
Narendra Wajapeyee et al.
CELL (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
Juan C. Acosta et al.
CELL (2008)
Senescence of activated stellate cells limits liver fibrosis
Valery Krizhanovsky et al.
CELL (2008)
S-Endoglin Expression Is Induced in Senescent Endothelial Cells and Contributes to Vascular Pathology
Francisco J. Blanco et al.
CIRCULATION RESEARCH (2008)
Many roads lead to oncogene-induced senescence
S. Courtois-Cox et al.
ONCOGENE (2008)
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
Kotb Abdelmohsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
NATURE REVIEWS CANCER (2008)
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
Zhaohui Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cellular senescence in cancer and aging
Manuel Collado et al.
CELL (2007)
An imperfect G2/M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells
Andrea Krempler et al.
CELL CYCLE (2007)
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
Zhenyu Ju et al.
NATURE MEDICINE (2007)
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Joao F. Passos et al.
PLOS BIOLOGY (2007)
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
Dan Liu et al.
CANCER RESEARCH (2007)
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
Nikolaj Dietrich et al.
EMBO JOURNAL (2007)
Chromosome breakage after G2 checkpoint release
Dorothee Deckbar et al.
JOURNAL OF CELL BIOLOGY (2007)
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Adrian P. Bracken et al.
GENES & DEVELOPMENT (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Aaheli Roy Choudhury et al.
NATURE GENETICS (2007)
Accumulation of senescent cells in mitotic tissue of aging primates
Jessie C. Jeyapalan et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova et al.
NATURE (2006)
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Raffaella Di Micco et al.
NATURE (2006)
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
Akiko Takahashi et al.
NATURE CELL BIOLOGY (2006)
The regulation of INK4/ARF in cancer and aging
William Y. Kim et al.
CELL (2006)
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
Christophe Denoyelle et al.
NATURE CELL BIOLOGY (2006)
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Viktor Janzen et al.
NATURE (2006)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
V. C. Gray-Schopfer et al.
BRITISH JOURNAL OF CANCER (2006)
A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation
Masashi Narita et al.
CELL (2006)
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
Roderik M. Kortlever et al.
NATURE CELL BIOLOGY (2006)
The power and the promise of oncogene-induced senescence markers
Manuel Collado et al.
NATURE REVIEWS CANCER (2006)
Lamin A-dependent nuclear defects in human aging
P Scaffidi et al.
SCIENCE (2006)
DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
O Moiseeva et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle
RE Verdun et al.
MOLECULAR CELL (2005)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
ZB Chen et al.
NATURE (2005)
BRAFE600-associated senescence-like cell cycle arrest of human naevi
C Michaloglou et al.
NATURE (2005)
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
GB Celli et al.
NATURE CELL BIOLOGY (2005)
The signals and pathways activating cellular senescence
I Ben-Porath et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
VG Gorgoulis et al.
NATURE (2005)
Reactive oxygen species as mediators of cellular senescence
R Colavitti et al.
IUBMB LIFE (2005)
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
EH Blackburn
FEBS LETTERS (2005)
Increased stability of the p16 mRNA with replicative senescence
WG Wang et al.
EMBO REPORTS (2005)
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
S Parrinello et al.
JOURNAL OF CELL SCIENCE (2005)
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
RG Zhang et al.
DEVELOPMENTAL CELL (2005)
Normal human fibroblasts are resistant to RAS-induced senescence
JA Benanti et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
OA Sedelnikova et al.
NATURE CELL BIOLOGY (2004)
In situ analyses of genome instability in breast cancer
K Chin et al.
NATURE GENETICS (2004)
p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress
FB Charrier-Savournin et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Significant role for p16INK4a in p53-independent telomere-directed senescence
JJL Jacobs et al.
CURRENT BIOLOGY (2004)
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
S Chang et al.
NATURE GENETICS (2004)
DNA damage checkpoint kinase Chk2 triggers replicative senescence
W Gire et al.
EMBO JOURNAL (2004)
Polycomb CBX7 has a unifying role in cellular lifespan
J Gil et al.
NATURE CELL BIOLOGY (2004)
Direct evidence from siRNA-directed knock down that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation
J Bond et al.
EXPERIMENTAL CELL RESEARCH (2004)
Regulation of murine telomere length by Rtel:: An essential gene encoding a helicase-like protein
H Ding et al.
CELL (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig et al.
MOLECULAR CELL (2004)
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
AK Meeker et al.
CLINICAL CANCER RESEARCH (2004)
Senescent fibroblasts resist apoptosis by downregulating caspase-3
R Marcotte et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways
D Lydall
JOURNAL OF CELL SCIENCE (2003)
Reversal of human cellular senescence:: roles of the p53 and p16 pathways
CM Beauséjour et al.
EMBO JOURNAL (2003)
Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts
F Baus et al.
EMBO JOURNAL (2003)
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
S Parrinello et al.
NATURE CELL BIOLOGY (2003)
Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
A Takaoka et al.
NATURE (2003)
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
WG Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
HS Yang et al.
MOLECULAR CELL (2003)
Erosion of the telomeric single-strand overhang at replicative senescence
SA Stewart et al.
NATURE GENETICS (2003)
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
H Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Association between telomere length in blood and mortality in people aged 60 years or older
RM Cawthon et al.
LANCET (2003)
Extensive allelic variation and ultrashort telomeres in senescent human cells
DM Baird et al.
NATURE GENETICS (2003)
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
W Zwerschke et al.
BIOCHEMICAL JOURNAL (2003)
E2F and Ras Synergize in Transcriptionally Activating p14(ARF) Expression
Eli Berkovich et al.
CELL CYCLE (2003)
Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins:: Implications for cellular senescence
DG Zhu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2002)
Connecting chromosomes, crisis, and cancer
RS Maser et al.
SCIENCE (2002)
Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts
JP de Magalhaes et al.
FEBS LETTERS (2002)
E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest
BD Rowland et al.
CANCER CELL (2002)
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
S Brookes et al.
EMBO JOURNAL (2002)
Oncogenic ras and p53 cooperate to induce cellular senescence
G Ferbeyre et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Senescence induced by altered telomere state, not telomere loss
J Karlseder et al.
SCIENCE (2002)
Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
SD Catz et al.
ONCOGENE (2001)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
A Krtolica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Role of p14ARF in replicative and induced senescence of human fibroblasts
WY Wei et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
P Krimpenfort et al.
NATURE (2001)
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
NE Sharpless et al.
NATURE (2001)
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
A Seluanov et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
J Sage et al.
GENES & DEVELOPMENT (2000)
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
SE Artandi et al.
NATURE (2000)
A regulatory link between ER-associated protein degradation and the unfolded-protein response.
R Friedlander et al.
NATURE CELL BIOLOGY (2000)
Is β-galactosidase staining a marker of senescence in vitro and in vivo?
J Severino et al.
EXPERIMENTAL CELL RESEARCH (2000)
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
KL Rudolph et al.
SCIENCE (2000)
Mitotic misregulation and human aging
DH Ly et al.
SCIENCE (2000)
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
H Yoshida et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
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