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NUCLEIC ACIDS RESEARCH (2021)
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models
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ONCOTARGET (2017)
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FRONTIERS IN ONCOLOGY (2017)
Use of biomarkers and imaging to evaluate the treatment effect of AUY922, an HSP90 inhibitor, in patients with HER2+ or ER+ metastatic breast cancer.
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JOURNAL OF CLINICAL ONCOLOGY (2017)
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MOLECULAR CANCER RESEARCH (2015)
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MOLECULAR CELL (2014)
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
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TRENDS IN CELL BIOLOGY (2014)
Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis
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CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
Hsp90, an unlikely ally in the war on cancer
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FEBS JOURNAL (2013)
TRAP-1, the mitochondrial Hsp90
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Evolution and function of diverse Hsp90 homologs and cochaperone proteins
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Broad action of Hsp90 as a host chaperone required for viral replication
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
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JOURNAL OF CLINICAL INVESTIGATION (2012)
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MOLECULAR BIOLOGY OF THE CELL (2012)
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NEW ENGLAND JOURNAL OF MEDICINE (2012)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer
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BREAST CANCER RESEARCH (2012)
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JOURNAL OF CLINICAL ONCOLOGY (2011)
An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC)
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JOURNAL OF CLINICAL ONCOLOGY (2011)
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NATURE CHEMICAL BIOLOGY (2011)
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PLOS ONE (2011)
Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation
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BMC CANCER (2010)
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions
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BMC CANCER (2010)
The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I
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JOURNAL OF IMMUNOLOGY (2010)
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MOLECULAR NEURODEGENERATION (2010)
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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging - A Mini-Review
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GERONTOLOGY (2009)
Expression of Hsp90 chaperome proteins in human tumor tissue
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2009)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
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JOURNAL OF CLINICAL INVESTIGATION (2009)
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Identification of Inhibitors of HSF1 Functional Activity by High-Content Target-Based Screening
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JOURNAL OF BIOMOLECULAR SCREENING (2009)
The Hsp90 molecular chaperone: an open and shut case for treatment
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BIOCHEMICAL JOURNAL (2008)
Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin
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CANCER RESEARCH (2008)
Role of acetylation and extracellular location of heat shock protein 90α in tumor cell invasion
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CANCER RESEARCH (2008)
NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
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CANCER RESEARCH (2008)
Mechanisms of proteasome inhibitor action and resistance in cancer
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DRUG RESISTANCE UPDATES (2008)
The ATPase cycle of the mitochondrial Hsp90 analog trap1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Hsp90 chaperone machinery
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Heat shock protein 90 inhibition in lung cancer
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JOURNAL OF THORACIC ONCOLOGY (2008)
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MOLECULAR AND CELLULAR BIOLOGY (2008)
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PROTEOMICS (2008)
Targeting the oncogene and kinome chaperone CDC37
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NATURE REVIEWS CANCER (2008)
Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells
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CANCER RESEARCH (2007)
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2-overexpressing breast cancer: A phase I Dose-Escalation study
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JOURNAL OF CLINICAL ONCOLOGY (2007)
Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis
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CANCER SCIENCE (2007)
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STRUCTURE (2007)
Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
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BLOOD (2007)
High HSP90 expression is associated with decreased survival in breast cancer
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CANCER RESEARCH (2007)
Extracellular heat shock protein-90α:: linking hypoxia to skin cell motility and wound healing
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EMBO JOURNAL (2007)
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins
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CURRENT MEDICINAL CHEMISTRY (2007)
Inhibition of Hsp90 with synthesis macrolactones: Synthesis and structural and biological evaluation of ring and conformational analogs of radicicol
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CHEMISTRY & BIOLOGY (2006)
Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery
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ORGANIC LETTERS (2006)
17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation
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ONCOGENE (2006)
Hsp90 inhibitors: Small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation
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MEDICINAL RESEARCH REVIEWS (2006)
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma
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CANCER RESEARCH (2006)
Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90 - Evidence that coumarin antibiotics disrupt Hsp90 dimerization
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Targeting chaperones in transformed systems - a focus on Hsp90 and cancer
G Chiosis
EXPERT OPINION ON THERAPEUTIC TARGETS (2006)
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Hsp90: A novel target for cancer therapy
David B. Solit et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
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CANCER RESEARCH (2005)
The HSP90 family of genes in the human genome: Insights into their divergence and evolution
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GENOMICS (2005)
Structure of unliganded GRP94, the endoplasmic reticulum Hsp90 - Basis for nucleotide-induced conformational change
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phase I pharmacokinetic and pharmacodynarnic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
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JOURNAL OF CLINICAL ONCOLOGY (2005)
Constantly updated knowledge of hsp90
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JOURNAL OF BIOCHEMISTRY (2005)
Endothelial cell regulation of matrix metalloproteinases
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CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2005)
Heat shock protein 90α-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta
HT Lei et al.
CIRCULATION RESEARCH (2004)
Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
P Workman
CANCER LETTERS (2004)
Inhibition of Hsp90: a new strategy for inhibiting protein kinases
AS Sreedhar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
P Meyer et al.
EMBO JOURNAL (2004)
Targeting multiple signal transduction pathways through inhibition of Hsp90
H Zhang et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2004)
Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide
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ORGANIC LETTERS (2004)
Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone
RM Immormino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness
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NATURE CELL BIOLOGY (2004)
Structure of the N-terminal domain of GRP94 - Basis for ligand specificity and regulation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
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NATURE (2003)
Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site
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EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
GP Lotz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Development of small molecule Hsp90 inhibitors: Utilizing both forward and reverse chemical genomics for drug identification
L Neckers
CURRENT MEDICINAL CHEMISTRY (2003)
Sti1 is a non-competitive inhibitor of the Hsp90 ATPase - Binding prevents the N-terminal dimerization reaction during the ATPase cycle
K Richter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90
Gabriela Chiosis et al.
CURRENT CANCER DRUG TARGETS (2003)
Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone Aha1
B Panaretou et al.
MOLECULAR CELL (2002)
Binding of ATP to heat shock protein 90 - Evidence for an ATP-binding site in the C-terminal domain
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Stimulation of the weak ATPase activity of human Hsp90 by a client protein
SH McLaughlin et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90 - N-terminal nucleotide binding unmasks a C-terminal binding pocket
C Soti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
CHIP is a U-box-dependent E3 ubiquitin ligase -: Identification of Hsc70 as a target for ubiquitylation
JH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Stable association of hsp90 and p23, but not hsp70, with active human telomerase
HL Forsythe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
G Chiosis et al.
CHEMISTRY & BIOLOGY (2001)
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
MG Marcu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
hsp70 interacting protein hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1
KC Kanelakis et al.
BIOCHEMISTRY (2000)
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins
MG Marcu et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
GHKL, an emergent ATPase/kinase superfamily
R Dutta et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
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