4.7 Article

Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration

期刊

出版社

MDPI
DOI: 10.3390/ijms23031039

关键词

dental implants; maxilla; mice (knockout); osseointegration; osteopontin; titanium; tooth extraction

资金

  1. Japan Society for the Promotion of Science (JSPS) Fellows [19J11806]
  2. Grants-in-Aid for Scientific Research [19J11806] Funding Source: KAKEN

向作者/读者索取更多资源

This study analyzed the effects of various OPN modified protein/peptides coatings on the healing patterns of the bone-implant interface. The results showed that rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.
After dental implantation, osteopontin (OPN) is deposited on the hydroxyapatite (HA) blasted implant surface followed by direct osteogenesis, which is significantly disturbed in Opn-knockout (KO) mice. However, whether applying OPN on the implant surface promotes direct osteogenesis remains unclarified. This study analyzed the effects of various OPN modified protein/peptides coatings on the healing patterns of the bone-implant interface after immediately placed implantation in the maxilla of four-week-old Opn-KO and wild-type (WT) mice (n = 96). The decalcified samples were processed for immunohistochemistry for OPN and Ki67 and tartrate-resistant acid phosphatase histochemistry. In the WT mice, the proliferative activity in the HA binding peptide-OPN mimic peptide fusion coated group was significantly higher than that in the control group from day 3 to week 1, and the rates of OPN deposition and direct osteogenesis around the implant surface significantly increased in the recombinant-mouse-OPN (rOPN) group compared to the Gly-Arg-Gly-Asp-Ser peptide group in week 2. The rOPN group achieved the same rates of direct osteogenesis and osseointegration as those in the control group in a half period (week 2). None of the implant surfaces could rescue the direct osteogenesis in the healing process in the Opn-KO mice. These results suggest that the rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据