☆ 4.7 Review

Hepatocellular Carcinoma in Chronic Viral Hepatitis: Where Do We Stand?

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Gastroenterology & Hepatology

HCC risk stratification after cure of hepatitis C in patients with compensated advanced chronic liver disease

Georg Semmler et al.

Summary: The study developed risk stratification algorithms for de novo HCC development after SVR in patients with ACLD. Parameters such as post-treatment AFP, alcohol consumption, age, LSM, and albumin accurately predicted de novo HCC development and stratified patients into low- and high-risk groups. These algorithms identified approximately two-thirds of patients with cACLD as having a low risk of <1%/year for HCC development, showing effectiveness in risk assessment and surveillance.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis

Victor Sapena et al.

Summary: This meta-analysis assessed the risk of HCC recurrence following DAA administration in HCV-related cirrhosis and HCC patients. Results showed an increased risk of recurrence and death in patients treated with DAAs, but no significant difference was observed in comparison to the DAA-unexposed group. Factors influencing recurrence included alpha-fetoprotein levels, pre-DAA recurrence history, patient performance status, and tumor burden.

GUT (2022)

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Article Gastroenterology & Hepatology

A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure

Javier Ampuero et al.

Summary: This study aimed to develop an easy-to-apply strategy for accurately classifying the risk of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) patients after sustained virological response (SVR).

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Surveillance for hepatocellular carcinoma with a 3-months interval in extremely high-risk patients does not further improve survival

Filippo Pelizzaro et al.

Summary: Increasing the surveillance interval from 3 to 6 months for cirrhotic patients with viral etiology did not result in a reduction of patients diagnosed at advanced cancer stages or an increase in the likelihood of receiving curative treatments.

DIGESTIVE AND LIVER DISEASE (2022)

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Article Gastroenterology & Hepatology

Noninvasive Risk Stratification After HCV Eradication in Patients With Advanced Chronic Liver Disease

Georg Semmler et al.

Summary: This study confirms the predictive value of noninvasive markers (LSM and VITRO) in determining the development of hepatic decompensation and hepatocellular carcinoma in patients with chronic liver disease caused by hepatitis C after cure. By combining these markers, it is possible to more accurately identify the risk of hepatic decompensation in patients in the future.

HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Letter to the Editor: Tenofovir vs. Entecavir on Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma After Surgical Resection

Guandou Yuan et al.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

The changing scenario of hepatocellular carcinoma in Italy: an update

Francesca Garuti et al.

Summary: In Italy, over the last 15 years, there has been a gradual increase in age of HCC patients, a rise in non-viral cases, and improvements in clinical management. Different treatment methods have shown positive outcomes, leading to an overall increase in survival rates.

LIVER INTERNATIONAL (2021)

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Article Immunology

Viral infections and the efficacy of PD-(L)1 inhibitors in virus-related cancers: Head and neck squamous cell carcinoma and hepatocellular carcinoma

Ting Liu et al.

Summary: This study found that patients with advanced head and neck squamous carcinoma and hepatocellular carcinoma could benefit from immune checkpoint inhibitor treatment, regardless of viral infection status. Patients with hepatitis B virus-associated hepatocellular carcinoma were more likely to benefit from ICI treatment compared to patients without viral infections.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma risk after viral response in hepatitis C virus-advanced fibrosis: Who to screen and for how long?

Adriana Ahumada et al.

Summary: Chronic hepatitis C virus (HCV) infection is closely related to the development of hepatocellular carcinoma (HCC), and lifelong surveillance is recommended even after sustained virological response (SVR), although not all patients have the same risk. Efforts have been made to develop predictive models and risk calculators to identify patients with very low HCC risk.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Oncology

Influence of Hepatocellular Carcinoma on Platelet Aggregation in Cirrhosis

Alberto Zanetto et al.

Summary: The study reveals a significant association between altered platelet function and hepatocellular carcinoma in patients with cirrhosis, suggesting the potential benefit of inhibiting hyper-functional platelets. The differences in platelet function may have important clinical implications for treatment.

CANCERS (2021)

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Review Immunology

Viral Status and Efficacy of Immunotherapy in Hepatocellular Carcinoma: A Systematic Review With Meta-Analysis

Ziniu Ding et al.

Summary: Viral etiology may not serve as a selection criteria for patients receiving ICIs in HCC, and viral status has limited impact on TIME remodeling during HCC tumorigenesis.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma

Mara Kloehn et al.

Summary: Hepatitis E virus infections are a leading cause of viral hepatitis in humans, contributing to around 3.3 million symptomatic cases and nearly 44,000 deaths annually. Recent findings suggest a potential link between chronic HEV infections and hepatocarcinogenesis, despite the rare documentation of HEV-induced hepatocellular carcinoma. The expanding clinical spectrum of HEV and the increasing evidence of chronic infections raise questions about the connection between HEV and HCC.

CANCERS (2021)

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Article Gastroenterology & Hepatology

Systemic treatment of HCC in special populations

Lorenza Rimassa et al.

Summary: Recent years have witnessed significant progress in the systemic treatment of hepatocellular carcinoma (HCC), but there is a lack of high-quality evidence for patients with various comorbidities. Future clinical trials should be designed to specifically include patients with comorbidities to improve the safety and efficacy of HCC treatment in these subgroups.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Hepatitis B virus-induced hepatocarcinogenesis: A virological and oncological perspective

Ferhat Arslan et al.

Summary: This article investigates the relationship between Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) by presenting epidemiological and microbiological data, accompanied by the principles of viral oncogenesis. Different correlations between HBV infection and HCC prevalence in various regions of the world suggest the presence of virus-independent phenomena for cancer development. It is important to review current knowledge and examine the relationship between HBV and HCC in light of the data presented.

JOURNAL OF VIRAL HEPATITIS (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The study investigated the impact of NASH on immunotherapy response in HCC patients and found that NASH-HCC may be less responsive to immunotherapy. Aberrant T cell activation caused by NASH-related tissue damage led to impaired immune surveillance in HCC patients.

NATURE (2021)

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Article Multidisciplinary Sciences

Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Tyng-Yuan Jang et al.

Summary: This study found that hepatitis D virus (HDV) viremia plays a crucial role in the development of hepatocellular carcinoma (HCC) in chronic hepatitis B patients undergoing nucleotide/nucleoside analogues (NAs) therapy, particularly in cirrhotic patients.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Unique Features of Hepatitis B Virus-Related Hepatocellular Carcinoma in Pathogenesis and Clinical Significance

Sheng-Han Wang et al.

Summary: HBV infection is a major risk factor for HCC globally, with chronic hepatitis B generating an inflammatory microenvironment that leads to genetic mutations in hepatocytes predisposing them to cancer. Male dominance in HBV-related HCC highlights the interplay between sex hormones and viral factors influencing carcinogenesis.

CANCERS (2021)

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Article Gastroenterology & Hepatology

New Treatments for Chronic Hepatitis B Virus/Hepatitis D Virus Infection

Lisa Sandmann et al.

CLINICS IN LIVER DISEASE (2021)

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Review Oncology

Immunotherapy in Hepatocellular Carcinoma

Claudia A. M. Fulgenzi et al.

Summary: Sorafenib has been the main treatment option for advanced HCC for over a decade, but the emergence of other targeted therapies and immunotherapy has expanded treatment options. However, resistance and long-term toxicity remain challenges for long-term survivorship.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mechanisms of DNA Methylation in Virus-Host Interaction in Hepatitis B Infection: Pathogenesis and Oncogenetic Properties

Dake Zhang et al.

Summary: Hepatitis B virus (HBV) infection leads to hepatic carcinoma development through genetic and epigenetic changes in liver cells, mediated by DNA methylation. Studies have shown that DNA methylation plays a crucial role in viral replication, cancer-related gene silencing, and hepatocellular carcinoma development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Epidemiology and risk-stratification of NAFLD-associated HCC

George N. Ioannou

Summary: NAFLD is projected to be the leading cause of hepatocellular carcinoma and is associated with risk factors such as obesity, diabetes, Hispanic ethnicity, and genetic polymorphisms. Lipotoxicity and oxidative DNA damage may lead to hepatocarcinogenesis, especially in the absence of cirrhosis. Validated models to identify high-risk patients for hepatocellular carcinoma in NAFLD are currently unavailable.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Risk of hepatocellular carcinoma in hepatitis B and D virus co-infected patients: A systematic review and meta-analysis of longitudinal studies

Habiba Kamal et al.

Summary: Hepatitis D virus (HDV) infection is associated with a 2-fold higher risk of hepatocellular carcinoma (HCC) development compared to hepatitis B virus (HBV) mono-infection, with a significant 6-fold increased risk noted among HIV/HBV/HDV triple-infected individuals. Adjusting for study design, quality, publication year, and follow-up duration did not significantly change the risk estimate. Surveillance strategies and new treatment options against HDV are warranted.

JOURNAL OF VIRAL HEPATITIS (2021)

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Article Oncology

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2-3 study

Zhenggang Ren et al.

Summary: The study aimed to assess the efficacy of sintilimab plus IBI305 versus sorafenib as a first-line treatment for unresectable HBV-associated hepatocellular carcinoma in China, showing significant overall survival and progression-free survival benefits with acceptable safety profiles.

LANCET ONCOLOGY (2021)

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Review Medicine, General & Internal

New Indications for Liver Transplantation

Alberto Zanetto et al.

Summary: Liver transplantation has seen remarkable improvements in post-transplant patient survival, graft survival, and quality of life in recent years. Due to these advancements, indications for liver transplantation are expanding to include clinical conditions historically considered exclusion criteria, showing survival advantages for patients. In this review, newer indications for liver transplantation such as alcoholic hepatitis, acute-on-chronic liver failure (ACLF), cholangiocarcinoma, and colorectal cancer metastases are discussed.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

More Pronounced Hypercoagulable State and Hypofibrinolysis in Patients With Cirrhosis With Versus Without HCC

Alberto Zanetto et al.

Summary: This study found that patients with cirrhosis with HCC exhibit significantly more prothrombotic hemostatic profile, contributing to their increased risk of portal vein thrombosis and cirrhosis progression. On the other hand, hypercoagulability in patients with decompensated cirrhosis is more likely a consequence of chronic liver disease rather than a driver for cirrhosis progression.

HEPATOLOGY COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The text discusses the impact of NASH on the development of HCC and the effect of immunotherapy, revealing the accumulation of exhausted and unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, anti-PD1 treatment led to an increase in HCC, with CD8(+) T cells contributing to this increase.

NATURE (2021)

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Article Gastroenterology & Hepatology

Tenofovir Is Associated With Lower Risk of Hepatocellular Carcinoma Than Entecavir in Patients With Chronic HBV Infection in China

Terry Cheuk-Fung Yip et al.

GASTROENTEROLOGY (2020)

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Article Immunology

Real-World Effectiveness From the Asia Pacific Rim Liver Consortium for HBV Risk Score for the Prediction of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated With Oral Antiviral Therapy

Hwai- Yang et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma prediction beyond year 5 of oral therapy in a large cohort of Caucasian patients with chronic hepatitis B

George V. Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Hepatitis C virus eradication with direct-acting antiviral improves insulin resistance

Francesco Paolo Russo et al.

JOURNAL OF VIRAL HEPATITIS (2020)

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Article Oncology

Simple scoring system for prediction of hepatocellular carcinoma occurrence after hepatitis C virus eradication by direct-acting antiviral treatment: All Kagawa Liver Disease Group Study

Joji Tani et al.

ONCOLOGY LETTERS (2020)

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Prioritisation and the initiation of HCC surveillance in CHB patients: lessons to learn from the COVID-19 crisis

Georgia Zeng et al.

GUT (2020)

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Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B

George Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2020)

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EASL recommendations on treatment of hepatitis C: Final update of the series

Jean-Michel Pawlotsky et al.

JOURNAL OF HEPATOLOGY (2020)

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Review Oncology

Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment

Srikanta Dash et al.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2020)

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Effect of Nucleos(t)ide Analogs on Patients with Intermediate and Advanced Hepatitis B Virus-Related Hepatocellular Carcinoma

Zhi-Wei Jian et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update on Interaction Between Oral Direct-Acting Antivirals for Chronic Hepatitis C Infection and Hepatocellular Carcinoma: Expert Review

Amit G. Singal et al.

GASTROENTEROLOGY (2019)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

Tatsuo Kanda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Oncology

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

Joseph Torresi et al.

BMC CANCER (2019)

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Article Oncology

Risk of Hepatocellular Carcinoma in Patients Treated With Entecavir vs Tenofovir for Chronic Hepatitis B A Korean Nationwide Cohort Study

Jonggi Choi et al.

JAMA ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Epidemiology and Management of Hepatocellular Carcinoma

Laura Kulik et al.

GASTROENTEROLOGY (2019)

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Treatment with direct-acting antivirals for HCV decreases but does not eliminate the risk of hepatocellular carcinoma

Federico Pinero et al.

LIVER INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication

Sarah Hofmann et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)

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Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Jorge A. Marrero et al.

HEPATOLOGY (2018)

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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Norah A. Terrault et al.

HEPATOLOGY (2018)

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Direct-acting antivirals do not increase the risk of hepatocellular carcinoma recurrence after local-regional therapy or liver transplant waitlist dropout

Annsa C. Huang et al.

HEPATOLOGY (2018)

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Editorial Material Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on hepatitis E virus infection

JOURNAL OF HEPATOLOGY (2018)

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HCV eradication induced by direct-acting antiviral agents reduces the risk of hepatocellular carcinoma

George N. Ioannou et al.

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EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Peter R. Galle et al.

JOURNAL OF HEPATOLOGY (2018)

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Mortality, liver transplantation and hepatic complications in patients with treatment-naive chronic hepatitis B treated with entecavir vs tenofovir

Byung Gyu Kim et al.

JOURNAL OF VIRAL HEPATITIS (2018)

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Temporal trend and risk determinants of hepatocellular carcinoma in chronic hepatitis B patients on entecavir or tenofovir

Yao-Chun Hsu et al.

JOURNAL OF VIRAL HEPATITIS (2018)

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Reversal of hypercoagulability in patients with HCV-related cirrhosis after treatment with direct-acting antivirals

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LIVER INTERNATIONAL (2018)

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Review Oncology

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CANCERS (2018)

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Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study

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WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Alberto Ferrarese et al.

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Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents

Fasiha Kanwal et al.

GASTROENTEROLOGY (2017)

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Hepatocellular Carcinoma Surveillance: The Road Ahead

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HEPATOLOGY (2017)

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Long-term effect of sustained virological response on hepatocellular carcinoma in patients with hepatitis C in Canada

Naveed Z. Janjua et al.

JOURNAL OF HEPATOLOGY (2017)

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Hepatocellular carcinoma in the absence of cirrhosis in patients with chronic hepatitis B virus infection

Maneerat Chayanupatkul et al.

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EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression

Reem Waziry et al.

JOURNAL OF HEPATOLOGY (2017)

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Polyclonal and monoclonal B lymphocytes response in HCV-infected patients treated with direct-acting antiviral agents

A. Schiavinato et al.

JOURNAL OF VIRAL HEPATITIS (2017)

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Article Gastroenterology & Hepatology

Dropout Rate From the Liver Transplant Waiting List Because of Hepatocellular Carcinoma Progression in Hepatitis C Virus-Infected Patients Treated With Direct-Acting Antivirals

Alberto Zanetto et al.

LIVER TRANSPLANTATION (2017)

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Review Virology

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

Thomas Tu et al.

VIRUSES-BASEL (2017)

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Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Sarah Blach et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

S. K. Sarin et al.

HEPATOLOGY INTERNATIONAL (2016)

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Letter Gastroenterology & Hepatology

Real-world risk score for hepatocellular carcinoma (RWS-HCC): a clinically practical risk predictor for HCC in chronic hepatitis B

Zhongxian Poh et al.

GUT (2016)

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Article Gastroenterology & Hepatology

Risk of Hepatocellular Carcinoma After Sustained Virological Response in Veterans With Hepatitis C Virus Infection

Hashem B. El-Serag et al.

HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Nomogram for Individualized Prediction of Hepatocellular Carcinoma Occurrence in Hepatitis C Virus Cirrhosis (ANRS CO12 CirVir)

Nathalie Ganne-Carrie et al.

HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy

George Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy

Maria Reig et al.

JOURNAL OF HEPATOLOGY (2016)

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Review Gastroenterology & Hepatology

Incidence of hepatocellular carcinoma in untreated subjects with chronic hepatitis B: a systematic review and meta-analysis

Elena Raffetti et al.

LIVER INTERNATIONAL (2016)

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Article Gastroenterology & Hepatology

Four-year entecavir therapy reduces hepatocellular carcinoma, cirrhotic events and mortality in chronic hepatitis B patients

Tung-Hung Su et al.

LIVER INTERNATIONAL (2016)

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Article Gastroenterology & Hepatology

Liver transplantation for viral hepatitis in 2015

Alberto Ferrarese et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Metabolic alterations and hepatitis C: From bench to bedside

Ming-Ling Chang

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer

Toby Phesse et al.

CANCERS (2016)

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Review Biochemistry & Molecular Biology

Hepatocellular Carcinoma in Patients with a Sustained Response to Anti-Hepatitis C Therapy

Roberta D'Ambrosio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Gastroenterology & Hepatology

Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir

George V. Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2015)

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Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

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Nucleos(t)ide analogs in the prevention of hepatitis B virus related hepatocellular carcinoma

Bulent Baran

WORLD JOURNAL OF HEPATOLOGY (2015)

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Hepatitis D and hepatocellular carcinoma

Zaigham Abbas et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

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Racial Differences in the Progression to Cirrhosis and Hepatocellular Carcinoma in HCV-Infected Veterans

Hashem B. El-Serag et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

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Role of antiviral treatment for HCC prevention

Massimo Colombo et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2014)

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HCV Genotype 3 Is Associated With an Increased Risk of Cirrhosis and Hepatocellular Cancer in a National Sample of US Veterans With HCV

Fasiha Kanwal et al.

HEPATOLOGY (2014)

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Determinants of hepatocellular carcinoma in cirrhotic patients treated with nucleos(t)ide analogues for chronic hepatitis B

Yao-Chun Hsu et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

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Article Gastroenterology & Hepatology

Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis

Mirko Tarocchi et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma

Pengyuan Yang et al.

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Review Oncology

Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

Pierre G. Coulie et al.

NATURE REVIEWS CANCER (2014)

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Article Gastroenterology & Hepatology

Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B

A. K. Singal et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2013)

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Review Medicine, General & Internal

Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma A Meta-analysis of Observational Studies

Rebecca L. Morgan et al.

ANNALS OF INTERNAL MEDICINE (2013)

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Article Gastroenterology & Hepatology

Entecavir Treatment Reduces Hepatic Events and Deaths in Chronic Hepatitis B Patients With Liver Cirrhosis

Grace Lai-Hung Wong et al.

HEPATOLOGY (2013)

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Article Gastroenterology & Hepatology

Efficacy of pegylated interferon alpha-2b and ribavirin treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis C: A prospective, multicenter study

Eiichi Ogawa et al.

JOURNAL OF HEPATOLOGY (2013)

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Article Gastroenterology & Hepatology

Rise and fall of HCV-related hepatocellular carcinoma in Italy: a long-term survey from the ITA.LI.CA centres

Nora Cazzagon et al.

LIVER INTERNATIONAL (2013)

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Review Gastroenterology & Hepatology

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

Hashem B. El-Serag

GASTROENTEROLOGY (2012)

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Article Medicine, General & Internal

Association Between Sustained Virological Response and All-Cause Mortality Among Patients With Chronic Hepatitis C and Advanced Hepatic Fibrosis

Adriaan J. van der Meer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Transarterial Chemoembolization for Hepatitis B Virus-associated Hepatocellular Carcinoma: Improved Survival after Concomitant Treatment with Nucleoside Analogues

Hidenori Toyoda et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2012)

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Article Virology

Hepatitis D Virus Isolates with Low Replication and Epithelial-Mesenchymal Transition-Inducing Activity Are Associated with Disease Remission

Hsuan Hui Shih et al.

JOURNAL OF VIROLOGY (2012)

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Review Gastroenterology & Hepatology

Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma

Avijit Majumdar et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma

J. S. -W. Wong et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2011)

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Article Gastroenterology & Hepatology

HCV-Related Proteins Activate Kupffer Cells Isolated from Human Liver Tissues

Naohiro Hosomura et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

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Article Gastroenterology & Hepatology

Ultrasonographic Surveillance of Hepatocellular Carcinoma in Cirrhosis: A Randomized Trial Comparing 3-and 6-Month Periodicities

Jean-Claude Trinchet et al.

HEPATOLOGY (2011)

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Article Oncology

Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score

Hwai-I Yang et al.

LANCET ONCOLOGY (2011)

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Review Gastroenterology & Hepatology

NF-κB in the liver-linking injury, fibrosis and hepatocellular carcinoma

Tom Luedde et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)

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Review Oncology

Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad

Kari Nichole Nejak-Bowen et al.

SEMINARS IN CANCER BIOLOGY (2011)

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Article Gastroenterology & Hepatology

A Sustained Viral Response Is Associated With Reduced Liver-Related Morbidity and Mortality in Patients With Hepatitis C Virus

Amit G. Singal et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression

Gary L. Davis et al.

GASTROENTEROLOGY (2010)

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Article Oncology

Clinical Scoring System to Predict Hepatocellular Carcinoma in Chronic Hepatitis B Carriers

Vincent Wai-Sun Wong et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

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Review Gastroenterology & Hepatology

Mechanisms of HBV-related hepatocarcinogenesis

Christine Neuveut et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival

Valentina Santi et al.

JOURNAL OF HEPATOLOGY (2010)

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Review Gastroenterology & Hepatology

Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review

George V. Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Hepatitis Delta Virus Inhibits Alpha Interferon Signaling

Paolo Pugnale et al.

HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

S100A8 and S100A9 Are Novel Nuclear Factor Kappa B Target Genes During Malignant Progression of Murine and Human Liver Carcinogenesis

Julia Nemeth et al.

HEPATOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells

Fu-Tien Liao et al.

JOURNAL OF GENERAL VIROLOGY (2009)

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Editorial Material Gastroenterology & Hepatology

Risk of recurrence in hepatitis B-related hepatocellular carcinoma: Impact of viral load in late recurrence

Yujin Hoshida

JOURNAL OF HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B

Man-Fung Yuen et al.

JOURNAL OF HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma

J. J. Y. Sung et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)

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Article Cell Biology

Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins

Serena Chang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity

Yanchun Li et al.

FASEB JOURNAL (2007)

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Article Multidisciplinary Sciences

Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

Hua Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Biochemistry & Molecular Biology

TP53 mutations and hepatocellular carcinoma:: insights into the etiology and pathogenesis of liver cancer

S. P. Hussain et al.

ONCOGENE (2007)

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Article Gastroenterology & Hepatology

Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice

Yanyan Zheng et al.

HEPATOLOGY (2007)

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Article Biochemistry & Molecular Biology

The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage

ATC Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Medical Laboratory Technology

Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells

XD Zhang et al.

JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2005)

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Review Medicine, General & Internal

Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation

JG Herman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Article Gastroenterology & Hepatology

Histological outcome during long-term lamivudine therapy

JL Dienstag et al.

GASTROENTEROLOGY (2003)

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Review Biochemistry & Molecular Biology

Signaling networks that link cell proliferation and cell fate

RC Sears et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Review Gastroenterology & Hepatology

Hepatitis B virus X protein: a multifunctional viral regulator

S Murakami

JOURNAL OF GASTROENTEROLOGY (2001)

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Article Biochemistry & Molecular Biology

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis

TI Huo et al.

ONCOGENE (2001)

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Article Gastroenterology & Hepatology

Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B

G Fattovich et al.

GUT (2000)

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