期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms222212562
关键词
Ag NPs; Olea europaea; green synthesis; antioxidant; antimicrobial; cytotoxic
资金
- King Saud University, Riyadh, Saudi Arabia [RG-1435-065]
The green synthesized OE-Ag NPs exhibited excellent antibacterial activity against different bacterial strains, comparable to standard antibiotic drugs. They also showed superior cytotoxic efficacy against MCF-7 carcinoma cells compared to plant lead extract and Com-Ag NPs. Furthermore, OE-Ag NPs demonstrated higher biocompatibility with hMSC and 293T cells compared to Com-Ag NPs. These biological results suggest that OE-Ag NPs have potential applications in various biological and nutraceutical fields, opening up new possibilities for producing biocompatible nanoparticles with enhanced biological functionalities from plants.
Herein, we report the green synthesis of silver nanoparticles (OE-Ag NPs) by ecofriendly green processes using biological molecules of Olea europaea leaf extract. Green synthesized OE-Ag NPs were successfully characterized using different spectroscopic techniques. Antibacterial activity of OE-Ag NPs was assessed against four different bacteriological strains using the dilution serial method. The cytotoxic potential was determined against MCF-7 carcinoma cells using MTT assay in terms of cell viability percentage. Antioxidant properties were evaluated in terms of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. Biocompatibility was further examined by incubating the synthesized NPs with hMSC cells for 24 h. The results were demonstrated that synthesized OE-Ag NPs presented excellent log(10) reduction in the growth of all the tested bacterial strains, which as statistically equivalent (p > 0.05) to the standard antibiotic drug. Moreover, they also demonstrated excellent cytotoxic efficacy against the MCF-7 carcinoma cells compared to plant lead extract and Com-Ag NPs. Green synthesized OE-Ag NPs appeared more biocompatible to hMSC and 293T cells compared to Com-Ag NPs. Excellent biological results of the OE-Ag NPs might be attributed to the synergetic effect of NPs' properties and the adsorbed secondary metabolites of plant leaf extract. Hence, this study suggests that synthesized OE-Ag NPs can be a potential contender for their various biological and nutraceutical applications. Moreover, this study will open a new avenue to produce biocompatible nanoparticles with additional biological functionalities from the plants.
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