期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms222111912
关键词
microRNAs; E3 ubiquitin ligases; deubiquitinases; autophagy
资金
- National Natural Science Foundation of China [82172888, 31571454]
- Natural Science Foundation Project of CQ CSTC [cstc2020jcyj-msxmX0154]
This article summarized the latest advances in the regulation of autophagy by the crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases, highlighting the key roles played by their interaction in various diseases.
MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and important pathways in regulating protein degradation and signal transduction, in which E3 ubiquitin ligases and deubiquitinases (DUBs) play a decisive role. MiRNA and ubiquitination are involved in the regulation of most biological processes, including autophagy. Furthermore, in recent years, the direct interaction between miRNA and E3 ubiquitin ligases or deubiquitinases has attracted much attention, and the cross-talk between miRNA and ubiquitination system has been proved to play key regulatory roles in a variety of diseases. In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases.
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