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The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

期刊

出版社

MDPI
DOI: 10.3390/ijms23031255

关键词

oxidative stress; ocular diseases; antioxidant biomarkers; antioxidant therapy

资金

  1. Chang Gung Memorial Hospital [CLRPG3D0048]
  2. Ministry of Science and Technology [CMRPG3L1691]
  3. [110-2221-E-182A-006]

向作者/读者索取更多资源

This article summarizes and provides updates on the research and treatment methods of ocular degenerative diseases related to oxidative stress. The article reviews the oxidative damage that occurs in different areas of the eye and introduces the antioxidant mechanisms present in the eye as well as the ocular diseases that occur as a result of antioxidant imbalances and relevant biomarkers.
Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.

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