期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms222011221
关键词
tumor microenvironment; cytotoxic T cells; exhaustion
资金
- AIRC [IG-20148]
- Regione Toscana grant PRECISE-CLL (Bando Ricerca Salute 2018)
The tumor microenvironment, like the two-faced god Janus in Roman mythology, exhibits opposing activities where immune cells fight against tumor cells yet also contribute to their proliferation and spread, particularly cytotoxic T cells which can become exhausted during their killing activities.
Similar to Janus, the two-faced god of Roman mythology, the tumor microenvironment operates two opposing and often conflicting activities, on the one hand fighting against tumor cells, while on the other hand, favoring their proliferation, survival and migration to other sites to establish metastases. In the tumor microenvironment, cytotoxic T cells-the specialized tumor-cell killers-also show this dual nature, operating their tumor-cell directed killing activities until they become exhausted and dysfunctional, a process promoted by cancer cells themselves. Here, we discuss the opposing activities of immune cells populating the tumor microenvironment in both cancer progression and anti-cancer responses, with a focus on cytotoxic T cells and on the molecular mechanisms responsible for the efficient suppression of their killing activities as a paradigm of the power of cancer cells to shape the microenvironment for their own survival and expansion.
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