New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies

Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system.

Automated summary

Recent advances in studying molecular and cellular mechanisms of peripheral nerve regeneration have shown the nervous system's ability to repair itself. However, serious injuries pose a challenge, calling for new treatment strategies. Understanding the basic mechanisms of nerve regeneration and the role of exosomes can lead to the development of new clinical strategies for full regeneration in the peripheral nervous system.