期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms222212374
关键词
endocannabinoids system (ECS); bone remodeling; cannabinoid receptor type 2 (CB2R); osteoporosis; bone cancer
资金
- University of Pisa [PRA_2020_77]
- MIUR National Interest Research Projects (PRIN 2017) [2017SA5837]
Bone is a complex and dynamic tissue involved in various functions, with bone remodeling requiring the coordinated action of osteoblasts and osteoclasts and the involvement of numerous hormones and messenger molecules. The endocannabinoid system, a new player in skeletal health, shows potential for treating bone diseases associated with accelerated osteoclastic bone resorption.
Novel interest has arisen in recent years regarding bone, which is a very complex and dynamic tissue deputed to several functions ranging from mechanical and protective support to hematopoiesis and calcium homeostasis maintenance. In order to address these tasks, a very refined, continuous remodeling process needs to occur involving the coordinated action of different types of bone cells: osteoblasts (OBs), which have the capacity to produce newly formed bone, and osteoclasts (OCs), which can remove old bone. Bone remodeling is a highly regulated process that requires many hormones and messenger molecules, both at the systemic and the local level. The whole picture is still not fully understood, and the role of novel actors, such as the components of the endocannabinoids system (ECS), including endogenous cannabinoid ligands (ECs), cannabinoid receptors (CBRs), and the enzymes responsible for endogenous ligand synthesis and breakdown, is extremely intriguing. This article reviews the connection between the ECS and skeletal health, supporting the potential use of cannabinoid receptor ligands for the treatment of bone diseases associated with accelerated osteoclastic bone resorption, including osteoporosis and bone metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据