期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms222212125
关键词
gastric cancer; cynaroside; cell proliferation; migration and invasion; MET
资金
- National Natural Science Foundation of China [81872071]
- Chongqing Graduate Science and Technology Innovation Project [CYS20139]
- Fundamental Research Funds for the Central Universities [XYDS201912]
Cynaroside (Cy), a flavonoid glycoside compound found in plants, has shown anticancer activity in various cancers, but its role in gastric cancer has not been extensively reported. This study confirmed that Cy can inhibit cell growth, migration, invasion, and tumorigenesis in gastric cancer by blocking the MET/AKT/mTOR axis. The findings suggest that Cy may be a potential drug for the treatment of gastric cancer.
The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying degrees of anticancer activity in non-small cell lung cancer, cervical cancer, liver cancer, esophageal cancer and other cancers. However, there are no relevant reports about its role in gastric cancer. The MET/AKT/mTOR signaling pathway plays important roles in regulating various biological processes, including cell proliferation, apoptosis, autophagy, invasion and tumorigenesis. In this study, we confirmed that Cy can inhibit the cell growth, migration and invasion and tumorigenesis in gastric cancer. Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K. Therefore, the MET/AKT/mTOR axis may be an important target for Cy. In summary, Cy has anti-cancer properties and is expected to be a potential drug for the treatment of gastric cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据