期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms23010460
关键词
thyroid cancer; mitophagy; mitochondrial DNA mutation; mitochondrial dynamics; apoptosis
资金
- Russian Science Foundation [20-15-00337]
- Russian Science Foundation [20-15-00337] Funding Source: Russian Science Foundation
This paper discusses the relationship between the etiology of thyroid cancer and mitochondrial function, and explores the use of known drugs and induction of mitochondria-mediated apoptosis as a new direction in anti-thyroid cancer therapy.
Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria-primarily, the regulation of mitochondria-mediated apoptosis, Ca2+ homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.
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