期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms23031543
关键词
obesity; metabolic disease; syndrome; extracellular vesicles; adipose tissue; adipose stromal; stem cells (ASCs)
资金
- University of Chieti-Pescara [AT2020]
In the past decade, several compounds have been identified for treating obesity, but concerns about their efficacy and safety remain due to the complexity of the disease. Therefore, it is crucial to discover new factors involved in obesity induction and progression. Adipose stromal/stem cells release extracellular vesicles (EVs), which play an important role in regulating metabolic processes. However, there are advantages and disadvantages to using EVs as potential next-generation anti-obesity agents.
Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the contribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据