Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

Automated summary

This paper describes the synthesis of multilayer nanoparticles for the diagnosis and treatment of ischemic injuries. The nanoparticles consist of magnetite and silica, with quinacrine used as an anti-ischemic agent. The study involves surface modification, immobilization of quinacrine, and the formation of a chitosan coating to fix fluorophores and quantum dots as secondary radiation sources. The potential theranostic platform was tested in laboratory animals.