期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 49, 期 2, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2021.5070
关键词
cerebral infarcts; ischemic stroke; neuronal injury; mechanism; clinical management
Stroke is the leading cause of disabilities and cognitive deficits, and the majority of strokes are ischemic strokes resulting from transient or permanent occlusion of cerebral vessels. Ischemic strokes lead to brain infarcts and neuronal damage, the severity of which depends on various factors. This review provides an overview of the pathological background, mechanisms, and treatments of ischemic stroke and cerebral infarcts.
Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up-to-date treatments that have been applied to stroke and brain infarcts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据