期刊
出版社
WILEY
DOI: 10.1002/rcs.2335
关键词
biopsy; breast; cancer; chemotherapy; margin; micro surgery; nanotechnology; sensors; surgery; tumour
类别
资金
- Nano hesgarsazana salamat Arya Company
The study demonstrated the effectiveness of CDP in real-time detection of breast cavity side margins, showing a sensitivity of 91% in scoring these margins. It has the potential to achieve clear margins in neoadjuvant breast cancer cases after breast-conserving surgery.
Background Background Recently, a real-time system, named cancer diagnostic probe (CDP), has been developed to diagnose the presence of pre-neoplastic/neoplastic cells in breast cavity side margins. Detecting mechanism is real-time determination of the ROS/H2O2 released from cancer or atypical cells, through reverse Warburg effect and hypoxia glycolysis pathways. Aims Here, we designed a human model study based on real-time checking of 387 internal margins (IM) from 39 neoadjuvant breast cancer cases by CDP. Materials & Methods Each lesion was checked by entered needle sensor and electrical scores were recorded. The permanent pathology result of each tested lesion was our gold standard to evaluate CDP scoring. CDP results were compared with permanent pathology of tumour side margins (as a conventional margin evaluation procedure). Results Results showed that the sensitivity of CDP in scoring the cavity side margins of those cases is 91%. A total of 18 involved IM which had been detected by CDP were declared as free margins in pathology section of tumour side samples. Just five involved IM were missed by CDP. Discussions Such sensitivity revealed that metabolism based (here: hypoxia glycolysis) tracing of cancer cells show distinct electrochemical responses between clear and involved cavity side margin evaluation. Conclusion This human study showed the promising role of CDP to achieve clear margins after BCS of neoadjuvant cases.
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