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Article
Infectious Diseases
Alexandre Gaymard et al.
Summary: The emergence of the SARS-CoV-2 variant 201/501Y.V1 in France is concerning due to its increased transmissibility. Recent data shows that this variant is 52-69% more transmissible compared to previously circulating lineages, with a prevalence of 6.9% in the Paris region.
Article
Biochemistry & Molecular Biology
Houriiyah Tegally et al.
Summary: The study identified 16 new lineages of SARS-CoV-2 in South Africa between March and August 2020, with unique mutations not found elsewhere. Three lineages (B.1.1.54, B.1.1.56, and C.1) dominated during the country's first wave, accounting for approximately 42% of all infections. The C.1 lineage, with 16 nucleotide mutations including the D614G spike protein change, became the most geographically widespread by August 2020. Genomic surveillance played a crucial role in identifying the 501Y.V2 variant in South Africa in December 2020.
Article
Multidisciplinary Sciences
Nadege Neant et al.
Summary: The study found that age ≥ 65 years, male gender, and chronic pulmonary disease were risk factors associated with mortality from COVID-19. Viral dynamics post-infection independently predicted mortality risk, and pharmacological interventions could shorten time to viral clearance, reducing mortality rates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Multidisciplinary Sciences
Erik Volz et al.
Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.
Article
Multidisciplinary Sciences
Nuno R. Faria et al.
Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.
Article
Multidisciplinary Sciences
Terry C. Jones et al.
Summary: In a study of SARS-CoV-2 cases in Germany, it was found that younger subjects had lower viral loads but higher cell culture replication probabilities compared to older subjects. Additionally, 8% of subjects had viral loads above 10(9) copies per swab, with a third of them being presymptomatic, asymptomatic, or mildly symptomatic individuals with a mean age of 37.6 years. The B.1.1.7 lineage infections had a higher viral load and cell culture replication probability than non-B.1.1.7 subjects.
Editorial Material
Biochemistry & Molecular Biology
Yannis Michalakis et al.
Summary: Ct values are commonly used as proxies of SARS-CoV-2 viral load, but equating them may lead to flawed conclusions, as it is unknown whether Ct variation reflects viral load or gene expression.
TRENDS IN MICROBIOLOGY
(2021)
Article
Immunology
Stephanie Haim-Boukobza et al.
Summary: The variants of severe acute respiratory syndrome coronavirus 2 found in France during the study demonstrated a higher transmission advantage and more advanced spread than anticipated, raising concerns about the control of coronavirus disease epidemics.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Patrick G. T. Walker et al.
