Tip of the iceberg: erectile dysfunction and COVID-19

Article Andrology

Predictive factors of erectile dysfunction in Egyptian individuals after contracting COVID-19: A prospective case-control study

Hany Mohammed Saad et al.

Summary: This study found that erectile dysfunction (ED) in individuals who contracted COVID-19 is associated with testosterone levels, erectile function scores, anxiety, stress, smoking, baseline ED scores, and COVID-19 severity.

ANDROLOGIA (2022)

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Review Urology & Nephrology

Effects of SARS CoV-2, COVID-19, and its vaccines on male sexual health and reproduction: where do we stand?

Sharon P. Lo et al.

Summary: Extensive research has been conducted on the impact of COVID-19 and its vaccine on male sexual health and reproduction, focusing on viral tropism, male sexual function recovery, and the effects on male reproductive organs and hormones.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2022)

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Review Urology & Nephrology

Erectile dysfunction among patients and health care providers during COVID-19 pandemic: A systematic review

Ahmed M. Bakr et al.

Summary: The COVID-19 pandemic is associated with increased rates of erectile dysfunction (ED), with anxiety and depression exacerbating this increase. Healthcare providers are at higher risk for post-traumatic stress disorder (PTSD), which further increases the risk of ED.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2022)

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Article Urology & Nephrology

The way COVID-19 transforms our sexual lives

Issam Nessaibia et al.

Summary: During the outbreak, attention to the impact on sexual function was insufficient, with studies showing that COVID-19 infection can lead to sexual complications and erectile dysfunction. Following barrier gestures during face-to-face sexual intercourse can be challenging.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2022)

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Article Pharmacology & Pharmacy

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

Tiago J. Costa et al.

Summary: This study demonstrates that SARS-CoV-2 infection impairs mitochondrial function and activates TLR9 signaling in endothelial cells, leading to inflammatory responses and endothelial dysfunction. Targeting mitochondrial metabolic pathways may offer new therapeutic strategies for COVID-19.

VASCULAR PHARMACOLOGY (2022)

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Article Medicine, General & Internal

COVID-19 Infection Is Associated With New Onset Erectile Dysfunction: Insights From a National Registry

Kevin Y. Chu et al.

Summary: This study investigates the association between COVID-19 infection and erectile dysfunction. The results show a significant association between COVID-19 diagnosis and erectile dysfunction. Clinicians are recommended to consider the risk of erectile dysfunction in men with recent COVID-19 diagnoses.

SEXUAL MEDICINE (2022)

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Article Andrology

Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients

Giulia Rastrelli et al.

Summary: In male patients with SARS-CoV-2 pneumonia, lower testosterone levels are associated with poor prognosis and mortality, indicating a potential role for testosterone in determining clinical outcomes in COVID-19 patients.

ANDROLOGY (2021)

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Review Endocrinology & Metabolism

Addressing male sexual and reproductive health in the wake of COVID-19 outbreak

A. Sansone et al.

Summary: The COVID-19 pandemic poses a significant challenge to healthcare systems globally, with severe complications such as micro-thrombosis and DIC. Survivors of COVID-19 may face long-term consequences, including the development of erectile dysfunction, adding to the burden of the disease.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Article Virology

Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients

Ling Ma et al.

Summary: The study found that although the COVID-19 virus was not detected in the semen of male patients, there were abnormal levels of sex hormones in the COVID-19 group, with a negative correlation with white blood cell counts and C-reactive protein levels.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Editorial Material Psychiatry

The COVID-19 pandemic: an opportunity to make mental health a higher public health priority

Javed Latoo et al.

Summary: The COVID-19 pandemic has highlighted the importance of mental health and the potential long-term impact it may have on individuals. There is a need for increased attention and action to improve and maintain mental well-being in the face of such crises.

BJPSYCH OPEN (2021)

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Review Medicine, General & Internal

Love in the time of COVID-19: a scoping review on male sexual health

Jahanzeb Malik et al.

Summary: The COVID-19 pandemic has imposed an unprecedented socioeconomic burden worldwide. Critically ill patients may experience hyper inflammation leading to cytokine storm, while post-COVID-19 sexual dysfunction in males could be linked to endothelial dysregulation, subclinical hypogonadism, psychosocial issues, and pulmonary impairment. Further research is needed to explore this novel association between COVID-19 and male sexual and reproductive health issues.

JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES (2021)

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Article Medicine, General & Internal

Evaluation of the Sexual Functioning of Individuals Living in Turkey During the COVID-19 Pandemic: An Internet-Based Nationwide Survey Study

Nejdet Karsiyakali et al.

Summary: This study investigated the impact of the COVID-19 pandemic on sexual functioning and found a decrease in sexual intercourse frequency and sexual desire among participants during the pandemic, with a more significant decline observed in individuals living in metropolitan areas.

SEXUAL MEDICINE (2021)

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Letter Immunology

Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients

Xixiang Ma et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Letter Urology & Nephrology

Sexuality during COVID lockdown: a cross-sectional Italian study among hospital workers and their relatives

Aldo Franco De Rose et al.

Summary: The study investigated levels and correlates of sexual activity and depression during COVID-19 lockdown among hospital workers and their acquaintances in Italy. The findings showed significant differences between males and females in sexual satisfaction, sexual desire, and depressive symptoms, with a higher proportion of health care workers experiencing low sexual desire. Various factors such as age, gender, occupation, and relationship status were identified as predictors of low sexual desire.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2021)

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Article Urology & Nephrology

Sexual attitudes of healthcare professionals during the COVID-19 outbreak

Mehmet Gokhan Culha et al.

Summary: During the COVID-19 outbreak, healthcare workers experienced decreased sexual desire, frequency of sexual intercourse, and foreplay time. They also preferred less oral sex, less foreplay, and more non-face-to-face sexual intercourse positions.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2021)

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Article Urology & Nephrology

Influence of COVID-19 pandemic on sexuality: a cross-sectional study among couples in Turkey

Mehmet Ali Karagoz et al.

Summary: The COVID-19 pandemic has had an impact on couples' sexuality, leading to decreased sexual function scores, reduced frequency of sexual intercourse, and increased sexual avoidance and solitary sexual behaviors. However, couples who spent more time together during the pandemic reported better sexual function scores. Further studies are needed to better understand the effects of the pandemic on sexuality.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2021)

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Article Urology & Nephrology

The impact of COVID-19 pandemic on pornography habits: a global analysis of Google Trends

Fabio Zattoni et al.

Summary: This study demonstrated an increased interest in pornography and coronavirus-themed pornography after the outbreak of COVID-19 in nations with straight stay-at-home orders, showing significant increases in various keyword trends, particularly on popular sites like PornHub and Porn. Despite variations in interest levels among different countries, there was a noticeable surge in searches for coronavirus-themed pornography globally after the implementation of self-quarantine measures.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2021)

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Article Urology & Nephrology

SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study

Mustafa Kadihasanoglu et al.

Summary: This study compared male reproductive hormone levels between patients with COVID-19, non-COVID-19 respiratory tract infection cases, and controls, finding that COVID-19 is associated with decreased TT levels and increased LH and prolactin levels. More severe COVID-19 leads to greater reduction in TT levels and prolonged hospitalization.

JOURNAL OF SEXUAL MEDICINE (2021)

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Article Andrology

Severely low testosterone in males with COVID-19: A case-control study

Andrea Salonia et al.

Summary: This study revealed that male patients with COVID-19 had lower levels of androgens, particularly testosterone, upon hospital admission, indicating a high prevalence of hypogonadism. Furthermore, the research showed an independent association between SARS-CoV-2 infection and decreased testosterone levels, as well as a higher risk of hypogonadism. Lower testosterone levels were also linked to increased risk of ICU admission and death outcomes.

ANDROLOGY (2021)

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Article Medicine, General & Internal

The Impact of COVID-19 on Sexual Health: A Preliminary Framework Based on a Qualitative Study With Clinical Sexologists

Patricia M. Pascoal et al.

Summary: The study aims to explore the perspectives of clinical sexologists on the impact of COVID-19 on sexual health. Three main themes emerged from the findings: Clinical Focus, Remapping Relationships, and Reframing Technology Use.

SEXUAL MEDICINE (2021)

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Article Medicine, General & Internal

An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic

Dong Fang et al.

Summary: The study found that during the COVID-19 epidemic, a certain proportion of adult men experienced decreased sexual function, with risk factors including increased anxiety and depression, and decreased frequency of sexual activity.

SEXUAL MEDICINE (2021)

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Article Economics

The psychological burden of the COVID-19 pandemic severity

Kien Le et al.

Summary: The study reveals the negative impact of COVID-19 severity on the mental health of Americans. The research shows a positive correlation between the severity of the pandemic and the incidence of daily anxiety, worry, displeasure, and depression. Strengthening public spending on mental health during and post-pandemic is crucial.

ECONOMICS & HUMAN BIOLOGY (2021)

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Article Urology & Nephrology

The Relationship Between COVID-19 Confinement, Psychological Adjustment, and Sexual Functioning, in a Sample of Portuguese Men and Women

Joana Carvalho et al.

Summary: This study found that psychological adjustment during lockdown plays an important mediating role in the sexual functioning domain, having a greater impact on men than women. While confinement levels are not directly related to sexual functioning, psychological adjustment during lockdown predicts lower sexual functioning in both genders.

JOURNAL OF SEXUAL MEDICINE (2021)

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Article Andrology

Mask up to keep it up: Preliminary evidence of the association between erectile dysfunction and COVID-19

Andrea Sansone et al.

Summary: A study revealed a significantly higher prevalence of ED among COVID-19 patients, with COVID-19 having a significant effect on the development of ED. Individuals with ED were also found to be more likely to contract COVID-19, indicating a potential bidirectional association between the two conditions.

ANDROLOGY (2021)

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Article Urology & Nephrology

Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

Kadir Karkin et al.

Summary: The study reveals that COVID-19 may cause Erectile Dysfunction (ED) and high testosterone levels increase the severity of the disease, leading to a higher rate of hospitalization in the intensive care unit.

ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA (2021)

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Review Urology & Nephrology

European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction

Andrea Salonia et al.

Summary: This study presents a summary of the European Association of Urology (EAU) guidelines on male sexual and reproductive health published in 2021. It covers topics such as late-onset hypogonadism, erectile dysfunction, premature ejaculation, and haemospermia, providing recommendations for diagnosis and treatment of these common conditions in men.

EUROPEAN UROLOGY (2021)

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Review Cell Biology

COVID-19 and male reproductive system: pathogenic features and possible mechanisms

Arash Ardestani Zadeh et al.

Summary: Severe COVID-19 patients exhibit multiorgan dysfunction, with potential involvement of the male reproductive system and implications for male fertility. Further research is needed to explore the underlying mechanisms and potential impact on male infertility in survivors of COVID-19.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

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Review Reproductive Biology

Coronavirus disease and male fertility: a systematic review

Mobina Fathi et al.

Summary: It is recommended to evaluate gonadal function in males infected with COVID-19 to determine the presence of the virus in seminal fluid, assess its impact on the reproductive system, and sexual transmissibility. Further research is needed to fully understand the effects of SARS-CoV-2 on the male reproductive system and viral transmission risk.

MIDDLE EAST FERTILITY SOCIETY JOURNAL (2021)

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Article Urology & Nephrology

Women's Sexual Health During the Pandemic of COVID-19: Declines in Sexual Function and Sexual Pleasure

Leonor de Oliveira et al.

Summary: This systematic review focused on women's sexual health during the COVID-19 pandemic, with findings showing a decrease in sexual function and satisfaction among women in various countries. Gender inequalities were found to contribute to lower sexual function and satisfaction indices, potentially exacerbating the pleasure gap between men and women.

CURRENT SEXUAL HEALTH REPORTS (2021)

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Article Andrology

COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical , and Ultrastructural Study of the Human Penis

Eliyahu Kresch et al.

Summary: The study identified the presence of COVID-19 virus in penile tissue long after initial infection, as well as suggested that widespread endothelial cell dysfunction from COVID-19 infection may contribute to erectile dysfunction. This study lays the groundwork for further research into the molecular mechanisms by which COVID-19 infection leads to ED.

WORLD JOURNAL OF MENS HEALTH (2021)

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Article Public, Environmental & Occupational Health

Sex in the Time of COVID-19: Results of an Online Survey of Gay, Bisexual and Other Men Who Have Sex with Men's Experience of Sex and HIV Prevention During the US COVID-19 Epidemic

Rob Stephenson et al.

Summary: This study explored changes in sexual behavior and HIV prevention measures among gay, bisexual, and other men who have sex with men during the COVID-19 lockdown. Findings showed an increase in sexual activity during the lockdown period, with some individuals believing that sex could transmit COVID-19. Despite the increase in sexual partners, participants did not feel the need to reduce the number of partners, and increased sexual activity was associated with substance use.

AIDS AND BEHAVIOR (2021)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Oncology

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N=4532)

M. Montopoli et al.

ANNALS OF ONCOLOGY (2020)

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Letter Reproductive Biology

Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients

Ci Song et al.

BIOLOGY OF REPRODUCTION (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Review Biochemistry & Molecular Biology

Cytokine storm intervention in the early stages of COVID-19 pneumonia

Xinjuan Sun et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

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Article Obstetrics & Gynecology

Effect of the COVID-19 pandemic on female sexual behavior

Bahar Yuksel et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2020)

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Article Urology & Nephrology

How sexual medicine is facing the outbreak of COVID-19: experience of Italian urological community and future perspectives

Andrea Cocci et al.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2020)

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Review Infectious Diseases

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

Jing Yang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Editorial Material Medicine, Research & Experimental

SARS-CoV-2: a storm is raging

Savannah F. Pedersen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Virology

Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19

Hao Cheng et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Urology & Nephrology

Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in China

Weiran Li et al.

JOURNAL OF SEXUAL MEDICINE (2020)

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Article Urology & Nephrology

Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in the United Kingdom

Louis Jacob et al.

JOURNAL OF SEXUAL MEDICINE (2020)

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Article Urology & Nephrology

Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in Portugal

Joana Carvalho et al.

JOURNAL OF SEXUAL MEDICINE (2020)

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Article Infectious Diseases

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Meng-Yuan Li et al.

INFECTIOUS DISEASES OF POVERTY (2020)

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Article Medicine, General & Internal

Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19

Harmony R. Reynolds et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Hematology

COVID-19 and the endothelium

F. Jung et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2020)

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Article Endocrinology & Metabolism

Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study

Selahittin Cayan et al.

AGING MALE (2020)

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Article Physiology

Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?

Rama Satyanarayana Raju Kalidhindi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Article Urology & Nephrology

Love in the Time of COVID-19: Sexual Function and Quality of Life Analysis During the Social Distancing Measures in a Group of Italian Reproductive-Age Women

Michele Carlo Schiavi et al.

JOURNAL OF SEXUAL MEDICINE (2020)

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Review Medicine, General & Internal

The psychological impact of COVID-19 on the mental health in the general population

G. Serafini et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2020)

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Review Cell Biology

The coagulopathy, endotheliopathy, and vasculitis of COVID-19

Toshiaki Iba et al.

INFLAMMATION RESEARCH (2020)

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Letter Urology & Nephrology

Italian males recovering from mild COVID-19 show no evidence of SARS-CoV-2 in semen despite prolonged nasopharyngeal swab positivity

Carlo Pavone et al.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2020)

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Review Clinical Neurology

Impact of COVID-19 pandemic on mental health in the general population: A systematic review

Jiaqi Xiong et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Clinical Neurology

The psychological burden of the COVID-19 pandemic and associated lockdown measures: Experience from 4000 participants

Waleed Burhamah et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Review Critical Care Medicine

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

Stephanie Pons et al.

CRITICAL CARE (2020)

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Review Endocrinology & Metabolism

From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome

M. I. Maiorino et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2018)

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Article Psychology, Clinical

Validation of the Sexual Inhibition and Sexual Excitation Scales (SIS/SES) in Portugal: Assessing Gender Differences and Predictors of Sexual Functioning

Ana Luisa Quinta Gomes et al.

ARCHIVES OF SEXUAL BEHAVIOR (2018)

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Article Urology & Nephrology

Psychological and Interpersonal Dimensions of Sexual Function and Dysfunction

Lori Brotto et al.

JOURNAL OF SEXUAL MEDICINE (2016)

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Article Cell Biology

Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice

Hye Eun Yoon et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Psychology, Clinical

Personality Traits, Sexual Problems, and Sexual Orientation: An Empirical Study

Maria Manuela Peixoto et al.

JOURNAL OF SEX & MARITAL THERAPY (2016)

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Article Urology & Nephrology

The Relationship Between Metabolic Syndrome, Its Components, and Erectile Dysfunction: A Systematic Review and a Meta-Analysis of Observational Studies

Huseyin Besiroglu et al.

JOURNAL OF SEXUAL MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction A Systematic Review and Meta-Analysis of Cohort Studies

Charalambos V. Vlachopoulos et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2013)

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Review Medicine, Research & Experimental

Aging and vascular endothelial function in humans

Douglas R. Seals et al.

CLINICAL SCIENCE (2011)

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Article Urology & Nephrology

Personality Traits and Psychopathology on Male Sexual Dysfunction: An Empirical Study

Ana Luisa Quinta Gomes et al.

JOURNAL OF SEXUAL MEDICINE (2011)

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Article Cardiac & Cardiovascular Systems

Erectile Dysfunction and Risk of Cardiovascular Disease Meta-Analysis of Prospective Cohort Studies

Jia-Yi Dong et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Review Urology & Nephrology

Anatomy, Physiology, and Pathophysiology of Erectile Dysfunction

Christian Gratzke et al.

JOURNAL OF SEXUAL MEDICINE (2010)

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Article Urology & Nephrology

Psychological Determinants of Erectile Dysfunction: Testing a Cognitive-Emotional Model

Pedro J. Nobre

JOURNAL OF SEXUAL MEDICINE (2010)

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Review Urology & Nephrology

Endothelial dysfunction in diabetic erectile dysfunction

B. Musicki et al.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2007)

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Tip of the iceberg: erectile dysfunction and COVID-19

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