期刊
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
卷 73, 期 5, 页码 630-637出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2022.2027889
关键词
Skeletal muscle; ageing; resveratrol; capillaries; inflammation; MyHC; Pecam-1; CD31; Cox-2
资金
- Regione Toscana Grant Bando Salute 2009 [132]
- MIUR-Finanziamento delle attivita base di ricerca (FFABR)
Sarcopenia, a condition that causes muscle loss and functional deficits, starts around the age of 40. A recent study showed that long-term supplementation with Resveratrol can counteract sarcopenia in mice. In a short-term treatment of middle-aged mice with Resveratrol, a decrease in muscle inflammation was observed.
Sarcopenia starts around the age of 40, causes the loss of 8% of muscle mass every 10 years, and is accompanied by functional deficit, chronic low-grade inflammation, and can result in several negative health outcomes. Considering the early and gradual onset of sarcopenia, the time window of the potential interventions could be crucial for the exertion of a beneficial effect. We recently showed that the long-term supplementation with Resveratrol contrasts sarcopenia in naturally ageing C57BL/6 mice. Aiming to understand the effects of a short term treatment, we administered intraperitoneally middle aged male mice with 20 mg/kg body weight Resveratrol daily for 5 weeks. Although we could not observe major differences in the histological properties of SKMs, we detected a significant decrease of Cox-2 in RES-treated muscles, confirming the anti-inflammatory action of Resveratrol, and suggesting that its anti-inflammatory action precedes modifications to SKM fibres.
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