Application of Hybridization Chain Reaction (HCR) in Electrochemical Analysis

With the bloom of DNA nanotechnology, diverse DNA amplification strategies have been designed and applied in bioassays. Among them, hybridization chain reaction (HCR) is prevalent because of its advantages of simplicity, enzyme-free and isothermal amplification. HCR-based electrochemical biosensors have been widely used in broad fields of food safety, environmental monitor and disease diagnosis. This review highlights the progress in HCR-based electrochemical biosensors which are divided based on the types of signal reporters.

Automated summary

This review highlights the progress of HCR-based electrochemical biosensors in different types of signal reporters, which have advantages of simplicity, enzyme-free, and isothermal amplification.