期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 2, 页码 760-770出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.65258
关键词
Doxorubicin; cardiotoxicity; oxidative stress; cell death
资金
- National Key R&D Program of China [2018YFC1311300]
- Fundamental Research Funds for the Central Universities [2042018kf1032]
- Development Centre for Medical Science and Technology National Health and Family Planning Commission of the People's Republic of China (The prevention and control project of cardiovascular disease) [2016ZX-008-01]
- National Natural Science Foundation of China [81870299]
- Guiding Fund of Renmin Hospital of Wuhan University [RMYD2018M39]
- Science and Technology Planning Projects of Wuhan [2018061005132295]
This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
Cancer is a destructive disease that causes high levels of morbidity and mortality. Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use places survivors at risk for cardiotoxicity. Many studies have demonstrated that multiple factors are involved in DOX-induced acute cardiotoxicity. Among them, oxidative stress and cell death predominate. In this review, we provide a comprehensive overview of the mechanisms underlying the source and effect of free radicals and dependent cell death pathways induced by DOX. Hence, we attempt to explain the cellular mechanisms of oxidative stress and cell death that elicit acute cardiotoxicity and provide new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
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