期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 193, 期 -, 页码 1499-1506出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.10.213
关键词
Pyruvate kinase M2; Leukemia; Modulators
资金
- Natural Science Foundation of Zhejiang Province [LZ18C190001]
- National Natural Science Foundation of China [31972821, 22077109, 21775131]
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products [2010DS700124-ZZ2008]
- General Scientific Research Project of Education of Zhejiang Province [Y202147351]
- Starting Research Fund of Ningbo University [421912073]
- Science and Technology Development Fund, Macau SAR [0007/2020/A1]
- University of Macau [MYRG2019-00002-ICMS]
- Hong Kong Baptist University
- Health and Medical Research Fund [HMRF/14150561]
- SKL-QRCM (UM)
Glycolysis is a crucial step for cellular respiration, and PKM2 plays a key role in tumor cell metabolism and proliferation. Through both aerobic glycolysis and non-metabolic pathways, PKM2 contributes to leukemic proliferation, differentiation, and drug resistance.
Glycolysis is an important step in respiration and provides energy for cellular processes. Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, plays an important role in tumor cell metabolism and proliferation. It is also specifically overexpressed in leukemia cells and contributes to leukemic proliferation, differentiation, and drug resistance through both aerobic glycolysis and non-metabolic pathways. In this review, the functions and regulatory roles of PKM2 are firstly introduced. Then, the molecular mechanisms of PKM2 in leukemogenesis are summarized. Next, reported PKM2 modulators and their anti-leukemia mechanisms are described. Finally, the current challenges and the potential opportunities of PKM2 inhibitors or agonists in leukemia therapy are discussed.
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