期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 197, 期 -, 页码 121-130出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.12.106
关键词
Cotton fibers; Nanocomposite; Zinc oxide; Wound healing; Wound dressing
This study presents a new design for antimicrobial wound bandages, which use cotton fibers reinforced with elastic compression straps and incorporate a wound healing biocomposite. The dressings showed a faster and more complete healing process compared to control groups, and also exhibited significant antimicrobial activity against pathogenic microorganisms commonly found in wounds.
In this present work, a new design for antimicrobial wound bandages is presented. The wound dressings were prepared using cotton fibers reinforced with elastic compression straps and secured with a polyester fabric of tight mesh size. The cotton pads were doped with a wound healing biocomposite, composed of chitosan, glycogen, and ZnO nanoparticles (CG@ZnONPs) previously formulated through a green process. The size of ZnONPs in the prepared CG@ZnONPs was 30-80 nm. The cotton pads impregnated with the CG@ZnONPs nanocomposite were characterized using FTIR, SEM, EDX, TGA, and DTGA methods. Moreover, the prepared dressings were tested on a number of intentionally injured rats. In this experiment, the % contraction of the treated wounds was monitored and compared to that of a control group of wounded rats, to which only sterile gauzes were applied. The results showed a much faster and an almost complete healing of rats treated with the synthesized dressings and the results were further confirmed by histopathological examination. The dressings were also found to exert a significant antimicrobial activity against a number of pathogenic microorganisms, generally encountered in common wounds, and could therefore be recommended to be a novel biomedical application for a fast, successful, and flawless wounds healing process.
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