期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 193, 期 -, 页码 1727-1733出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.11.010
关键词
Gentiana straminea Maxim; Polysaccharides; 3D graphene-based decoloration column; Anti-inflammatory activity
资金
- National Natural Science Foundation of China [31901794]
- Shaanxi Provincial Science Fund for Distinguished Young Scholars [2018JC-011]
- Young Talent Fund of University Association for Science and Technology in Shaanxi, China [2019-02-03]
- Qinghai Special Project of the Innovation Platform for Basic Conditions of the Scientific Research of China [2020-ZJ-T05]
- Qinghai Natural Science Foundation Project of China [2019-ZJ-904]
- Function development and technical innovation project of instrument of Chinese Academy of Sciences [2022gl09]
- Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resource [2021-ZJ-Y14]
- TangScholar by Cyrus Tang Foundation
By utilizing a flexible 3D graphene-based decoloration column, Gentiana straminea Maxim. polysaccharide was efficiently obtained and its anti-inflammatory activity was demonstrated, showcasing a promising potential for practical application in pharmaceutical field.
Gentiana straminea Maxim. exhibits various biological activities. However, the purification and functions of polysaccharides in Gentiana straminea Maxim. have never been reported. Herein, by proposing a flexible 3D graphene-based decoloration column (3DD column), Gentiana straminea Maxim. polysaccharide (GMP) was high-throughput obtained and its anti-inflammatory activity was investigated. Benefiting from the large macroporous network of 3D NH2 -graphene oxide hydrogel with selective adsorption towards pigments, the 3DD column exhibits high decoloration ratio (96.41%). In addition, the 3DD column provides superior practical functionality as compared to the traditional approaches, which are time-consuming and need toxic solvents, and exhibiting widespread-application for the purification of polysaccharide from other common plant species. More importantly, the decolored GMP as a natural product has promising anti-inflammatory activity on RAW264.7 cells without negative impact on cell viability. Overall, this work reveals a new functional polysaccharides and provides a flexible approach for polysaccharide decoloration, exhibiting a promising prospect for natural polysaccharides in practical application of pharmaceutical.
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