Brilliant glycans and glycosylation: Seq and ye shall find

Proteoglycosylation is the addition of monosaccharides or glycans to the protein peptide chain. This is a common post-translational modification of proteins with a variety of biological functions. At present, more than half of all biopharmaceuticals in clinic are modified by glycosylation. Most glycoproteins are potential drug targets and biomarkers for disease diagnosis. Therefore, in-depth study of glycan structure of glycoproteins will ultimately improve the sensitivity and specificity of glycoproteins for clinical disease detection. With the deepening of research, the function and application value of glycans and glycosylation has gradually emerged. This review systematically introduces the latest research progress of glycans and glycosylation. It encompasses six cancers, four viruses, and their latest discoveries in Alzheimer's disease, allergic diseases, congenital diseases, gastroin-testinal diseases, inflammation, and aging.

Automated summary

In-depth study of glycan structure of glycoproteins can improve their sensitivity and specificity in clinical disease detection. Glycans and glycosylation play important roles in biopharmaceuticals, as potential drug targets and biomarkers for many diseases.