期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 195, 期 -, 页码 294-301出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.12.020
关键词
Nanocatalysts; Reactive oxygen species; Bacterial cellulose; Injectability; Antibacterial
资金
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_1798]
- national first-class discipline program of Light Industry Technology and Engineering [LITE2018-21]
- Fundamental Research Funds for the Central Universities [JUSRP52007A]
This study demonstrates that nanocatalysts can act as an alternative strategy for treating bacterial infections with high antibacterial efficacy. A carbon-based nanozyme doped with copper atoms was prepared and used for antibacterial treatment, along with temperature-responsive nanogels as carriers.
Reactive oxygen species (ROS) for treating bacterial infection is an alternative strategy to overcome the drawbacks such as bacterial resistance of commonly used antibiotics. Nanocatalysts have been proved highly effective in regulating intracellular ROS level due to their intrinsic enzymes-mimicking ability. Herein, we prepared a carbon-based nanozyme doped with copper atoms with peroxidase mimetic activity to catalyze the decomposition of bio-safety dosage of H2O2 to highly reactive (OH)-O-center dot radicals for antibacterial treatment. Furthermore, we designed the thermo-responsive nanogels consisting of bacterial cellulose nanowhiskers as the carrier of the nanozyme. The obtained nanogels displayed remarkable intelligent response to temperature change with sol-gel transition temperature of similar to 33 degrees C and in situ gel forming ability. Moreover, the nanogels exhibited excellent biocompatibility in vitro, along with remarkable antibacterial efficacy which could inactivate 6.36 log of S. aureus and 6.01 log of E. coli in 3 h, respectively. The findings provide a novel strategy for advancing the development of nanocatalysts-based responsive biomaterials for treating bacterial infections.
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