期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 51, 期 13-14, 页码 1099-1119出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2021.08.007
关键词
Cryptosporidium; Giardia; Taxonomy; Epidemiology
类别
资金
- Guangdong Major Project of Basic and Applied Basic Research, China [2020B0301030007]
- 111 Project, China [D20008]
Protozoan parasites Cryptosporidium and Giardia are significant causes of diarrhoea worldwide, with numerous named species and genotypes recognized. Zoonotic transmission plays an important role in the epidemiology, and the development of sequencing tools provides evidence for this. Comparative whole genome sequencing offers key information on genetic mechanisms and enables future One Health management.
The protozoan parasites Cryptosporidium and Giardia are significant causes of diarrhoea worldwide and are responsible for numerous waterborne and foodborne outbreaks of diseases. Over the last 50 years, the development of improved detection and typing tools has facilitated the expanding range of named species. Currently at least 44 Cryptosporidium spp. and >120 genotypes, and nine Giardia spp., are recognised. Many of these Cryptosporidium genotypes will likely be described as species in the future. The phylogenetic placement of Cryptosporidium at the genus level is still unclear and further research is required to better understand its evolutionary origins. Zoonotic transmission has long been known to play an important role in the epidemiology of cryptosporidiosis and giardiasis, and the development and application of next generation sequencing tools is providing evidence for this. Comparative whole genome sequencing is also providing key information on the genetic mechanisms for host specificity and human infectivity, and will enable One Health management of these zoonotic parasites in the future. (c) 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
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