Associations of CD14 variants with the triglyceride levels and risk of myocardial infarction in an Eastern Chinese Han population

Background: CD14 is crucial in the progression of myocardial infarction (MI). Several studies have explored the association between the risk of MI and the CD14 C-260 T polymorphism, but have reported inconsistent results. Methods: This study analyzed the association of the CD14 C-260 T polymorphism with susceptibility to MI. Totally, 240 MI patients and 298 normal subjects were included. The association between MI risk and the target polymorphism was assessed using 95% confidence intervals and odds ratios obtained through logistic regression. Results: The T allele of the CD14 C-260 T polymorphism was linked with an elevated risk of MI in Chinese Han people; subgroup analysis indicated that this effect was associated with smoking, male gender, and hypertension. In addition, the data revealed that different genotype carriers of the CD14 C-260 T polymorphism showed significantly distinct TG levels in MI patients. Conclusion: Totally, the T allele of the CD14 C-260 T polymorphism is associated with an elevated risk of MI.

Automated summary

The T allele of the CD14 C-260 T polymorphism is associated with an elevated risk of MI in Chinese Han individuals, with subgroup analysis suggesting a correlation with smoking, male gender, and hypertension. Moreover, different genotype carriers of the CD14 C-260 T polymorphism showed significantly distinct TG levels in MI patients.