期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 100, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2021.108085
关键词
Neuroinflammation; Bavachin; Microglia; A20; NF-KB
Bavachin exerts anti-neuroinflammatory effects by inhibiting NF-KB signaling and regulating the ubiquitin-editing enzyme A20 complex, which has important clinical significance for the potential treatment of neurological disorders.
Neuroinflammation is a major pathophysiological contributor to the progression of the central nervous system disorders. Bavachin is a natural product belonging to the flavonoid class. The anti-neuroinflammatory effect and the molecular mechanisms are not well understood. In this study, we found bavachin can exert antineuroinflammatory effect via inhibition of nuclear factor-kappa B (NF-KB) signaling. We found that bavachin can obviously upregulate the expression of A20 (TNFAIP3) in microglial cells. Further studies suggested siRNAA20 knockdown treatment can attenuate the inhibitory effects of bavachin on neuroinflammation. We further found bavachin can increase the interaction of ubiquitin-editing enzyme A20 complex including A20, Tax1binding protein 1 (TAX1BP1) and Itch, the subsequently downregulated the K63-ubiquitination of TNF receptor associated factor 6 (TRAF6) and NF-KB signaling pathway. Altogether, our results indicated that bavachin exerted anti-neuroinflammatory effects through inhibition of NF-KB signaling mediated by regulation of ubiquitin-editing enzyme A20 complex. Our finding has important clinical significance for the potential application of bavachin in the treatment of neurological disorders.
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