期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 99, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2021.107995
关键词
COVID-19; SARS-CoV-2; Thrombocytopenia; Platelet; Pathophysiology; Prognosis
资金
- Shahid Beheshti University of Medical Sciences (Tehran, Iran)
This study reviews the role of platelets in COVID-19 and emphasizes their importance in patient management and prognostic assessment. Platelet reduction is closely associated with the occurrence of coagulopathy, affecting the severity of the disease.
Despite endorsed and exponential research to improve diagnostic and therapeutic strategies, efforts have not yet converted into a better prospect for patients infected with the novel coronavirus (2019nCoV), and still, the name of SARS-CoV-2 is coupled with numerous unanswered questions. One of these questions is concerning how this respiratory virus reduces the number of platelets (PLTs)? The results of laboratory examinations showed that about a quarter of COVID-19 cases experience thrombocytopenia, and more remarkably, about half of these patients succumb to the infection due to coagulopathy. These findings have positioned PLTs as a pillar in the management as well as stratifying COVID-19 patients; however, not all the physicians came into a consensus about the prognostic value of these cells. The current review aims to unravel the contributory role of PLTs s in COVID-19; and also to summarize the original data obtained from international research laboratories on the association between COVID-19 and PLT production, activation, and clearance. In addition, we provide a special focus on the prognostic value of PLTs and their related parameters in COVID-19. Questions on how SARS-CoV-2 induces thrombocytopenia are also responded to. The last section provides a general overview of the most recent PLT-or thrombocytopenia-related therapeutic approaches. In conclusion, since SARS-CoV-2 reduces the number of PLTs by eliciting different mechanisms, treatment of thrombocytopenia in COVID-19 patients is not as simple as it appears and serious cautions should be considered to deal with the problem through scrutiny awareness of the causal mechanisms.
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