期刊
INTERNAL MEDICINE
卷 61, 期 7, 页码 1063-1065出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.7902-21
关键词
Lambert-Eaton myasthenic syndrome (LEMS); treatment algorithm; electrophysiological examination; 3; 4-diaminopyridine; cholinesterase inhibitors
资金
- Health and Labour Sciences Research Grants for research on intractable diseases (Neuroimmunological Disease Research Committee) from the Ministry of Health, Labor and Welfare of Japan
We report two LEMS patients who responded dramatically to cholinesterase inhibitors. Cholinesterase inhibitors were effective in improving gait disturbance and autonomic symptoms in LEMS patients.
We herein report two P/Q-type voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS) patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When symptomatic treatment was started with pyridostigmine, gait disturbance was ameliorated, and his modified Rankin scale decreased from 4 points to 3 points. Patient 2, a 68-year-old man, had cancer-free LEMS. Distigmine bromide was very effective and ameliorated not only his gait disturbance but also autonomic symptoms, and his modified Rankin scale decreased from 2 points to 1 point. Cholinesterase inhibitors alone may be effective in a small portion of LEMS patients.
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