期刊
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 139, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2021.103676
关键词
Innate behaviors; Ecdysis; Sleep; Locomotor activity; Courtship; Oviposition
资金
- International Brain Research Organization (IBRO)
- Agencia Nacional de Promocion de la Investigacion, el Desarrollo Tecnologico y la Innovacion [PICT-2018 0862]
- FONDECYT INICIACION grant [11190601]
- CONICYT [21191720]
- FONDECYT [1180403]
- Centro Interdisciplinario de Neurociencia de Valparaiso (CINV) Millennium Institute - Millennium Scientific Initiative of the Ministerio de Economia, Fomento y Turismo [P09-022-F]
- CONICET
The study explored the role of Orcokinins in behavior and reproduction in fruit flies, finding that knockdown of the orcokinin gene led to abnormal courtship behavior in male flies and reduced egg production. Results suggest that Orcokinins play an important role in reproductive success in fruit flies.
In animals, neuropeptidergic signaling is essential for the regulation of survival and reproduction. In insects, Orcokinins are poorly studied, despite their high level of conservation among different orders. In particular, there are currently no reports on the role of Orcokinins in the experimental insect model, the fruit fly, Drosophila melanogaster. In the present work, we made use of the genetic tools available in this species to investigate the role of Orcokinins in the regulation of different innate behaviors including ecdysis, sleep, locomotor activity, oviposition, and courtship. We found that RNAi-mediated knockdown of the orcokinin gene caused a disinhibition of male courtship behavior, including the occurrence of male to male courtship, which is rarely seen in wildtype flies. In addition, orcokinin gene silencing caused a reduction in egg production. Orcokinin is emerging as an important neuropeptide family in the regulation of the physiology of insects from different orders. In the case of the fruit fly, our results suggest an important role in reproductive success.
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