SNS donors as mimic to enzymes, chemosensors, and imaging agents

This review summarizes multidentate SNS ligands as enzyme imitating models, chemosensors, and bioimaging agents. Due to the obvious prevalence of bioactive sulfur and nitrogen donors, SNS ligands have a substantial biological value. Sulfur-based tridentate ligands are frequently used to mimic the active sites of metalloproteins to truly comprehend enzyme active sites and have been used as building blocks to construct innovative model complexes. Metal complexes of such ligands, including Cu, Ni, Zn, Fe, Mo, and Co have been thoroughly investigated to imitate the enzymes. Chemosensors based on SNS donor and their functionalized polymers used for cation/anion and molecule detection, such as Al3+, Pb2+, Hg2+, F-, and glucose, have also been reviewed. The carcinogenic and psychiatric activity of trace metal 99mTc and 186Re complexes with tridentate SNS moiety has been discussed in vivo, in vitro, and in silico for brain ailments, schizophrenic, and other neurodegenerative problems. Ligands having SNS moiety used as a radiotracer in bioimaging have been discussed. Other biological activity observed in gold complexes of SNS ligands, which have been administered as an antiparasitic medicine to manage Chagas disease, malaria, and other infectious diseases, has also been covered.

Automated summary

This review summarizes the applications of multidentate SNS ligands as enzyme imitating models, chemosensors, and bioimaging agents. SNS ligands, containing bioactive sulfur and nitrogen donors, have significant biological value. They have been used to mimic the active sites of metalloproteins and to construct model complexes. Metal complexes of SNS ligands have been investigated to imitate enzymes and chemosensors based on SNS donors have been studied for cation/anion and molecule detection. The role of SNS ligands in bioimaging and their biological activities, including treating diseases and managing infections, have also been discussed.