期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 158, 期 4, 页码 537-543出版社
SPRINGER
DOI: 10.1007/s10517-015-2803-2
关键词
multipotent mesenchymal stromal cells; umbilical cord; fibroblasts; fetal liver; surface markers
资金
- Russian Research Foundation [14-15-00648]
- Russian Science Foundation [14-15-00648] Funding Source: Russian Science Foundation
Expression of 20 surface markers was analyzed in cultures of mesenchymal stromal cells of the umbilical cord, fibroblasts from adult and fetal human skin, and fi broblast-like cells of fetal liver was analyzed by fl ow cytometry. The studied cultures did not express hemopoietic cells markers, but were positive for CD73, CD90, and CD105 markers recommended by the International Society of Cell Therapy for the identifi cation of the multipotent mesenchymal stromal cells. Fetal liver fi broblast-like cells were positive for CD54; this marker was absent in skin fi broblast cultures, but was expressed by umbilical cord mesenchymal stromal cells. Further study of these cells revealed a minor subpopulation of cells co-expressing CD24 and CD90 or CD24 and CD54. We hypothesized that these cells probably participate in epithelial mesenchymal transition.
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