期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 159, 期 1, 页码 58-61出版社
SPRINGER
DOI: 10.1007/s10517-015-2889-6
关键词
PI3K; MAPK; alkaloids; progenitor cells; regenerative medicine
资金
- President of Russian Federation for Young Russian Scientists - Doctors of Sciences [MD-893.2013.7]
- Tomsk State University Competitiveness Improvement Program
We studied the role of intracellular signaling molecules PI3K, DeDD K ERK1/2, and NEuro38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and NEuro38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and NEuro38 reduced the intensity of progenitor cell differentiation.
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