Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine

We studied the role of intracellular signaling molecules PI3K, DeDD K ERK1/2, and NEuro38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and NEuro38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and NEuro38 reduced the intensity of progenitor cell differentiation.