Cellular landscape of tumour microenvironment in prostate cancer

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Clinicopathological significance and prognostic value of cancer-associated fibroblasts in prostate cancer patients

Zhenyu Wu et al.

Summary: This study found that a high density of CAFs in PCa patients may be associated with advanced-stage disease, higher Gleason scores, lymphatic metastases, higher PSA levels, and poor biochemical recurrence-free survival. Furthermore, bioinformatics analysis revealed that CAFs may regulate tumor progression and recurrence through ECM modification, PI3K-Akt signaling pathway, and regulation of cytoskeleton.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

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Article Biochemistry & Molecular Biology