期刊
IMMUNOLOGICAL REVIEWS
卷 305, 期 1, 页码 165-178出版社
WILEY
DOI: 10.1111/imr.13042
关键词
comparative immunology; evolution; gene regulations; transcription factors; viral
类别
资金
- National Institute of General Medical Sciences [1R35GM128822]
Recent advances in regulatory genomic technologies have led to significant progress in understanding the transcriptional networks underlying mammalian immune responses. Epigenomic studies profiling immune cells have revealed detailed genome-wide maps of regulatory elements, with endogenous retroviruses unexpectedly emerging as allies in regulating human immune systems.
In recent years, there has been significant progress toward understanding the transcriptional networks underlying mammalian immune responses, fueled by advances in regulatory genomic technologies. Epigenomic studies profiling immune cells have generated detailed genome-wide maps of regulatory elements that will be key to deciphering the regulatory networks underlying cellular immune responses and autoimmune disorders. Unbiased analyses of these genomic maps have uncovered endogenous retroviruses as an unexpected ally in the regulation of human immune systems. Despite their parasitic origins, studies are finding an increasing number of examples of retroviral sequences having been co-opted for beneficial immune function and regulation by the host cell. Here, we review how endogenous retroviruses have given rise to numerous regulatory elements that shape the epigenetic landscape of host immune responses. We will discuss the implications of these elements on the function, dysfunction, and evolution of innate immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据