☆ 4.8 Editorial Material

Many Langerhans make light work of skin immunity

IMMUNITY (2021)

Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds et al.

Summary: The skin establishes a complex cellular network early in embryonic development to provide biophysical and immunological protection. The study found an enrichment of innate immune cells in skin during the first trimester, as well as clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. Additionally, a reemergence of prenatal vascular endothelial cell and macrophage cellular programs was observed in atopic dermatitis and psoriasis lesional skin.

SCIENCE (2021)

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Article Immunology

Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation

Xiaochun Liu et al.

Summary: This study identified two steady-state (LC1 and LC2) and two activated LC subsets in human skin epidermis and LCs derived from CD34(+) hemopoietic stem cells. LC1 were characterized as classical LCs mainly related to innate immunity and antigen processing, while LC2 were similar to monocytes or myeloid dendritic cells, involving in immune responses and leukocyte activation. These distinct human LC subsets require different developmental regulation and orchestrate reciprocal functions.

IMMUNITY (2021)

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Article Multidisciplinary Sciences