期刊
ADDICTION
卷 111, 期 2, 页码 272-279出版社
WILEY
DOI: 10.1111/add.13173
关键词
Africa; biomarker; brief intervention; HIV; phosphatidylethanol; self-report; trend; Uganda; unhealthy alcohol use
资金
- US National Institutes of Health [R01AA018631, U01AA020776, K24AA022586, K01AA021671, P30DK026743]
AimsWe examined whether unhealthy alcohol consumption, which negatively impacts HIV outcomes, changes after HIV care entry overall and by several factors. We also compared using phosphatidylethanol (PEth, an alcohol biomarker) to augment self-report to using self-report alone. DesignA prospective 1-year observational cohort study with quarterly visits. SettingLarge rural HIV clinic in Mbarara, Uganda. ParticipantsA total of 208 adults (89 women and 119 men) entering HIV care, reporting any prior year alcohol consumption. MeasurementsUnhealthy drinking was PEth+ (50ng/ml) or Alcohol Use Disorders Identification Test-Consumption+ (AUDIT-C+, over 3 months, women 3; men 4). We calculated adjusted odds ratios (AOR) for unhealthy drinking per month since baseline, and interactions of month since baseline with perceived health, number of HIV symptoms, antiretroviral therapy (ART), gender and self-reported prior unhealthy alcohol use. FindingsThe majority of participants (64%) were unhealthy drinkers (PEth+ or AUDIT-C+) at baseline. There was no significant trend in unhealthy drinking overall [per-month AOR: 1.01; 95% confidence interval (CI)=0.94-1.07], while the per-month AORs were 0.91 (95% CI=0.83-1.00) and 1.11 (95% CI=1.01-1.22) when participants were not yet on ART and on ART, respectively (interaction P-value <0.01). In contrast, 44% were AUDIT-C+; the per-month AORs for being AUDIT-C+ were 0.89 (95% CI=0.85-0.95) overall, and 0.84 (95% CI=0.78-0.91) and 0.97 (95% CI=0.89-1.05) when participants were not on and were on ART, respectively. ConclusionsUnhealthy alcohol use among Ugandan adults entering HIV care declines prior to the start of anti-retroviral therapy but rebounds with time. Augmenting self-reported alcohol use with biomarkers increases the ability of current alcohol use measurements to detect unhealthy alcohol use.
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