Detection of Blood Glucose With Hemoglobin Content Using Compact Photonic Crystal Fiber

We have proposed Twin Elliptical Core Photonic Crystal Fiber (TEC-PCF) sensor for the detection of blood glucose level under the influence of hemoglobin components. The main featuring of the proposed biosensor is to detect the wide range of blood glucose content with enhanced sensitivity, by utilizing small length of the fiber. In order to achieve this, we have constructed asymmetric TEC-PCF where the elliptical core is filled by blood sample. The numerical sensing characteristics are evaluated using Finite Element Method (FEM). By varying hemoglobin concentrations as 120 g/L, 140 g/L and 160 g/L, we realize enhanced blood glucose sensing with detection range from 0 g/L to 100 g/L. The sensing performance of the proposed biosensor is studied through the coupling length and transmission power spectrum by calculation of effective index of the coupling mode. The obtained maximum wavelength sensitivity under the influence of 160 g/L hemoglobin content is 2.4 nm/(g/L) and 2.42 nm/(g/L) with fiber length of 0.245 mm and 0.215 mm for X and Y polarization, respectively. Further, limit of detection (LOD) is calculated under the influence of 160 g/L hemoglobin content is 0.375 mg/L and 0.372 mg/L for X and Y polarization, respectively. The proposed miniaturized sensing device can be integrated with microfluidic systems for the development of next-generation biosensor applications as point of- care and lab-on-a-chip.

Automated summary

The proposed Twin Elliptical Core Photonic Crystal Fiber (TEC-PCF) sensor allows for enhanced sensitivity in detecting a wide range of blood glucose levels with small fiber lengths, by adjusting hemoglobin concentrations. Studies show that by varying hemoglobin levels, the sensor can achieve maximum wavelength sensitivity and a low limit of detection, making it suitable for next-generation biosensor applications when integrated with microfluidic systems.