期刊
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
卷 71, 期 -, 页码 -出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2021.3133335
关键词
Optical fibers; Nanoparticles; Optical fiber sensors; Scanning electron microscopy; Sensitivity; Multicore processing; Splicing; Acetylcholine (ACh); etched fiber structure; gold nanoparticles (AuNPs); molybdenum disulfide (MoS2); optical fiber sensor; tapered fiber structure
资金
- Double-Hundred Talent Plan of Shandong Province
- Special Construction Project Fund for Shandong Province Taishan Mountain Scholars
- Natural Science Foundation of Shandong Province [ZR2020QC061]
- Liaocheng University, China [318051901, 31805180301, 31805180326]
- Science and Engineering Research Board, India [TAR/2018/000051]
- Fundacao para a Ciencia e a Tecnologia (FCT) [CEECIND/00034/2018]
- FCT/Ministry of Education and Science (MEC) [UIDB/50025/2020, UIDP/50025/2020]
This work investigates the fabrication of sensor structures by splicing tapered/etched multicore fiber probes with multimode fiber and immobilizing them with gold nanoparticles and molybdenum disulfide nanoparticles to enhance sensitivity. The morphology of the nanoparticles is examined using high-resolution transmission electron microscopy, and the immobilized optical fiber sensor structures are characterized using scanning electron microscopy and SEM-EDX. The functionalization of the acetylcholinesterase enzyme over the nanoparticle-immobilized probe increases sensor specificity. The developed sensor probes are tested for detecting various concentrations of acetylcholine, and performance analyses are performed. The developed tapered fiber sensor exhibits a high sensitivity and wide detection range.
In this work, tapered/etched multicore fiber (MCF) probes are spliced with multimode fiber (MMF) to fabricate the sensor structure. To improve sensitivity, gold nanoparticles (AuNPs) and molybdenum disulfide nanoparticles (MoS2-NPs) are used to immobilize both probes. Synthesized AuNPs and molybdenum disulfide (MoS2)-nanoparticles (NPs) have peak absorption wavelengths of 519 and 330 nm, respectively. High-resolution transmission electron microscopy is used to examine the morphology of the NPs. The scanning electron microscope (SEM) is used to characterize the NP-immobilized optical fiber sensor structures, and SEM-EDX is used to verify the NP-coating over fiber structure. The functionalization of the acetylcholinesterase enzyme over the NP-immobilized probe increases the specificity of the sensor later on. Finally, the developed sensor probes are tested by detecting various acetylcholine concentrations. In addition, performance analyses, such as reusability, reproducibility, and selectivity (in the presence of ascorbic acid, glucose, dopamine, and uric acid), are carried out, and proposed biosensors are experimentally evaluated. The developed tapered fiber sensor with a sensitivity of 0.062 nm/mu M can detect even very low concentrations, such as 14.28 mu M, over a wide detection range of 0-1000 mu M.
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