期刊
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
卷 29, 期 6, 页码 2351-2365出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TCST.2020.3036169
关键词
Hyperthermia; Tumors; Ultrasonic imaging; Acoustic beams; Observers; Magnetic resonance imaging; Transducers; High-intensity focused ultrasound; hyperthermia; model predictive control (MPC); offset-free control; oncology
资金
- Top Sector Life Sciences Health
- European Union via the IPaCT Project
Hyperthermia therapy is valuable in cancer treatment. A model predictive control setup is developed to improve temperature regulation in MR-HIFU treatments, effectively addressing plant-model mismatch and modeling errors in practice. In vivo experiments on porcine thigh muscle demonstrate the controller's performance.
Heating cancer cells over an extended period of time, referred to as hyperthermia, has been proven to enhance the effects of chemotherapy and radiotherapy without inducing additional toxicity or undesirable side effects, and is therefore considered a highly valuable adjuvant therapy in cancer treatment. In this work, a model predictive control (MPC) setup is developed for improving performance and robustness in regulating the temperature for magnetic-resonance-guided high-intensity focused ultrasound (MR-HIFU) hyperthermia treatments. The proposed control design incorporates a disturbance estimator as encountered in offset-free MPC that is able to remove the steady-state temperature error caused by plant-model mismatch. For the considered healthcare application, such modeling errors are inevitable in practice due to the high variability of tissue properties in patients, some of which even exhibit time- and temperature-dependent behavior due to the body's thermoregulatory response, combined with the fact that extensive model identification is undesirable in the clinic. The controller's performance is demonstrated by means of in vivo experiments on a porcine thigh muscle using a clinical MR-HIFU treatment setup.
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