期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 68, 期 11, 页码 3457-3468出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2021.3077802
关键词
Transducers; Ultrasonic imaging; Phased arrays; Magnetic resonance imaging; Skull; Head; Medical treatment; Focused ultrasound; image guided therapy; conformal phased arrays; personalised medicine
资金
- W. Garfield Weston Foundation
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01 EB003268]
- Canadian Institutes of Health Research, under grant the Temerty Chair in Focused Ultrasound Research at Sunnybrook Health Sciences Centre [FDN 154272]
- Beamish foundation
- Connor foundation
The study focused on implementing a skull-conformal phased array for ultrasound therapy with improved patient comfort. Results showed the feasibility and safety of patient-specific conformal ultrasound arrays for transcranial procedures, potentially accelerating the adoption of transcranial FUS therapy.
Objective: To implement a skull-conformal phased array for ultrasound-guided transcranial focused ultrasound therapy with improved patient comfort. Methods: Using patient-specific computed tomography and MRI neuroimaging data, tightly-conforming helmet scaffolds were designed computationally. The helmet scaffolds were designed to hold reusable transducer modules at near-normal incidence in an optimal configuration for the treatment location(s) of interest. Numerical simulations of trans-skull ultrasound propagation were performed to evaluate different conformal array designs and to compare with hemispherical arrays similar to those employed clinically. A 4096-element phased array was constructed by 3D printing a helmet scaffold optimised for an ex vivo human skullcap, and its performance was evaluated via benchtop and in vivo experiments. Results: Acoustic field measurements confirmed the system's ability to focus through human skull bone using simulation-based transcranial aberration corrections. Preliminary in vivo testing demonstrated safe trans-human skull blood-brain barrier (BBB) opening in rodents. Conclusion: Patient-specific conformal ultrasound phased arrays appear to be a feasible and safe approach for conducting transcranial BBB opening procedures. Significance: Skull-conformal phased arrays stand to improve patient comfort and have the potential to accelerate the adoption of transcranial FUS therapy by improving access to the technology.
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