期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 159, 期 3, 页码 344-347出版社
SPRINGER
DOI: 10.1007/s10517-015-2958-x
关键词
psychogenic stress; anxiety; galanin; posttraumatic stress disorder
Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockageof galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions - manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder.
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